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10526 IPO8

10526

IPO8

importin 8

protein-coding

Homo sapiens

基因描述

Type Description
Definition importin 8

研究结论

Date Results Publications
2017-04-08 12:17:00 the findings of the present study provided novel insights into the control of IPO8 transcription, and may enhance understanding regarding RUNX2 regulatory mechanisms in osteoblast differentiation, bone development, and degenerative bone disease. 27277970
2016-12-17 11:56:00 Our studies also suggest that nuclear entry is important for the prooncogenic activity of eIF4E, at least in this context. These findings position nuclear trafficking of eIF4E as a critical step in its regulation and position the importin 8-eIF4E complex as a novel therapeutic target. 27114554
2015-12-05 10:26:00 importin alpha8 functions as a cNLS receptor with distinct cargo specificity, and that heterodimerization by importin alpha8 is a novel regulatory mode of cNLS binding, in addition to the autoinhibitory regulation by the importin beta binding domain. 26220098
2014-06-28 13:48:00 Knockdown of IPO8 reduced the amount of nuclear p65 following TNF stimulation. IPO8 binding to p65 is NLS independent. 23906023
2010-01-21 00:00:00 Study provides evidence that Imp8 is required for cytoplasmic miRNA-guided gene silencing and affects nuclear localization of Ago proteins. 19167051

名称对应

Type IDs
Synonymous RANBP8
Gene
UniProtKB-ID: IPO8_HUMAN
UniprotKB: O15397
UniParc: UPI000191511E, UPI000013CEE9
EMBL: AK302260, U77494, AC012673, AC023426
Ensembl: ENSG00000133704
KO: hsa:10526
Nucleutide sequences
EMBL-CDS: BAH13659.1, AAB67052.1
Ensembl_TRS: ENST00000544829, ENST00000256079
Protein sequencees
Ensembl_PRO: ENSP00000444520, ENSP00000256079
RefSeq: XP_016874181.1, NP_001177924.1, NP_006381.2, XP_016874182.1, XP_016874180.1
Others
UniRef100: UniRef100_O15397
UniRef90: UniRef90_O15397
UniRef50: UniRef50_O95373
UniGene: Hs.505136
CCDS: CCDS53773.1, CCDS8719.1

全选

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研究热度

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