| Type | Description |
|---|---|
| Definition | tyrosyl-DNA phosphodiesterase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 12:20:00 | Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy. | 31878088 |
| 2011-01-01 11:34:00 | These findings provide evidence for TDP1 as a novel mitochondrial enzyme. | 21041670 |
| 2010-05-10 12:07:00 | The interaction with Lig3alpha is promoted by serine 81 that is located within a putative S/TQ site in the N-terminus domain of TDP1. | 20009512 |
| 2010-01-21 00:00:00 | Data indicate that TDP1 is required for neural homeostasis and reveal a widespread requisite for TDP1 function in response to acutely elevated levels of DNA topoisomerase I (Top1)-associated DNA strand breaks. | 17914460 |
| 2010-01-21 00:00:00 | This study provides a direct demonstration that Tdp1 repairs Topo I covalent lesions in vivo and suggests that spinocerebellar ataxia with axonal neuropathy (SCAN1) arises from the recessive neomorphic mutation H493R. | 17948061 |
| Type | IDs |
|---|---|
| Synonymous | 2810481F14Rik, 4921509N21Rik, AI838772, AW493413, E430034L06Rik, MLZ-501, SCAN1 |
| Gene |
UniProtKB-ID:
Q8C5A5_MOUSE,
Q6P1B8_MOUSE,
B8JJC1_MOUSE
UniprotKB:
Q8C5A5,
Q6P1B8,
B8JJC1
UniParc:
UPI00001E7612,
UPI000023392D,
UPI00000E9CBD
EMBL:
AC160931,
CT010436,
AK079006,
BC065162,
AK137004
Ensembl:
ENSMUSG00000021177
|
| Nucleutide sequences |
EMBL-CDS:
BAE23203.1,
BAC37502.1,
AAH65162.1
Ensembl_TRS:
ENSMUST00000153627,
ENSMUST00000021594
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000021594,
ENSMUSP00000118656
RefSeq:
XP_030102367.1,
XP_036013046.1,
XP_036013044.1,
NP_001366001.1,
XP_036013045.1,
XP_030102366.1,
NP_082630.2
|
| Others |
UniRef100:
UniRef100_B8JJC1,
UniRef100_Q6P1B8,
UniRef100_Q8C5A5
UniRef90:
UniRef90_Q8C5A5,
UniRef90_G3HBG4,
UniRef90_Q4G056
UniRef50:
UniRef50_Q8C5A5,
UniRef50_Q9NUW8
UniGene:
Mm.312323,
Mm.487464,
Mm.488658
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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