| Type | Description |
|---|---|
| Definition | cyclase associated actin cytoskeleton regulatory protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:53:00 | CAP2 is a Valuable Biomarker for Diagnosis and Prognostic in Patients with Gastric Cancer. | 30047046 |
| 2020-07-11 10:46:00 | CAP2 expression in ovarian cancer is an independent prognostic factor for recurrence-free survival. | 32211793 |
| 2020-05-23 12:09:00 | CAP2 joins other regulators of actin dynamics demonstrated to cause human genetic diseases. Our study is the first to demonstrate a mutation in CAP2 in human and a direct role for mutated CAP2 and perturbation of actin dynamics in the pathogenesis of DCM and possibly also conduction abnormalities in humans. | 30518548 |
| 2020-05-16 12:44:00 | Study used lysine-to-glutamine mutations to map the relevant lysines on actin for INF2 regulation. K50Q- and K61Q-actin, when bound to CAP2, inhibit full-length INF2 but not INF2 lacking inhibitory domain (DID). CAP WH2 domain binds INF2-DID with submicromolar affinity but has weak affinity for actin monomers, while INF2-C-terminal diaphanous autoregulatory domain binds CAP/K50Q-actin 5-fold better than CAP/WT-actin. | 31871199 |
| 2019-11-16 12:36:00 | CAP2 is highly expressed in gastric cancer tissues in close relation with the tumor progression. CAP2 is an independent risk factor for 5-year survival rate after radical gastrectomy for gastric cancer. | 31640951 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
CAP2_HUMAN,
Q5JPJ8_HUMAN
UniprotKB:
P40123,
Q5JPJ8
UniParc:
UPI0001914D58,
UPI000020D5A1,
UPI0000126EC6,
UPI0000373CD3
EMBL:
AL832154,
BC008481,
AL138824,
AL034372,
AK294215,
CH471087,
U02390,
AK293134,
AK312362,
CR457022
Ensembl:
ENSG00000112186
KO:
hsa:10486
|
| Nucleutide sequences |
EMBL-CDS:
AAA20587.1,
EAW55380.1,
BAH11460.1,
BAG35280.1,
BAH11700.1,
CAG33303.1,
AAH08481.1,
CAI46134.1
Ensembl_TRS:
ENST00000493172,
ENST00000229922,
ENST00000465994
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000229922,
ENSP00000417208,
ENSP00000418604
RefSeq:
NP_001350463.1,
NP_001350462.1,
NP_006357.1
|
| Others |
UniRef100:
UniRef100_Q5JPJ8,
UniRef100_P40123
UniRef90:
UniRef90_P40123
UniRef50:
UniRef50_P40123
UniGene:
Hs.132902
CCDS:
CCDS4539.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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