| Type | Description |
|---|---|
| Definition | Fanconi anemia, complementation group M |
| Date | Results | Publications |
|---|---|---|
| 2019-03-16 10:11:00 | The loss-of-function FANCM pathogenic variants (PV) increased ICL sensitivity in lymphocytes of patients and Fancm(DeltaC/DeltaC) spermatogonia.neither bone marrow failure nor cancer/tumor was detected in all the patients or adult Fancm(DeltaC/DeltaC) mice. These findings revealed male infertility to be a novel phenotype of human patients with a biallelic FANCM PV. | 29895858 |
| 2018-12-22 11:33:00 | Suppression of Rad52 expression in combination with FANCM knockout drastically reduces cell and tumor growth, suggesting a synthetic lethality interaction between these two genes. | 30022024 |
| 2010-01-21 00:00:00 | Fancm(Delta2/Delta2) mice also showed unique features atypical for Fanconi anemia mice, including underrepresentation of female Fancm(Delta2/Delta2) mice and decreased overall and tumor-free survival. | 19561169 |
| Type | IDs |
|---|---|
| Synonymous | AI427100, C730036B14Rik, D12Ertd364e |
| Gene |
UniProtKB-ID:
FANCM_MOUSE
UniprotKB:
Q8BGE5
UniParc:
UPI00000EB5C8,
UPI000044FEA2,
UPI00005C8A19,
UPI00000EAA71
EMBL:
AK053715,
AK173211,
AK050306,
AK084697,
AK086395
Ensembl:
ENSMUSG00000055884
KO:
mmu:104806
|
| Nucleutide sequences |
EMBL-CDS:
BAD32489.1,
BAC39257.2,
BAC34178.2,
BAC35487.1,
BAC39660.1
Ensembl_TRS:
ENSMUST00000058889
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000054797
RefSeq:
NP_001351376.1,
XP_006515403.1,
NP_849243.2,
XP_006515404.1
|
| Others |
UniRef100:
UniRef100_Q8BGE5
UniRef90:
UniRef90_Q8BGE5
UniRef50:
UniRef50_Q8IYD8
UniGene:
Mm.374847
CCDS:
CCDS25941.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员