| Type | Description |
|---|---|
| Definition | TGF-beta activated kinase 1 (MAP3K7) binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-30 11:09:00 | the present results indicated that miR889 inhibits the aggressive behaviors of nonsmall cell lung cancer (NSCLC) by directly targeting TAB1 mRNA, thus highlighting the importance of the miR889/TAB1 pathway in the malignant progression of NSCLC. | 31115539 |
| 2019-10-19 11:23:00 | multiple GPCR agonists utilize non-canonical TAB1-TAB2 and TAB1-TAB3-dependent p38 activation to promote endothelial inflammatory responses. | 30760523 |
| 2019-09-28 13:25:00 | Silencing of TAB1, but not TAK1, prevented p38MAPK activation, which is indicative of TAB1-mediated autophosphorylation of p38MAPK | 29893818 |
| 2019-03-09 12:35:00 | Based on the crystal structure of the p38alpha-TAB1 complex authors replaced threonine 185 of p38alpha with glycine (T185G) to prevent an intramolecular hydrogen bond with Asp150 from being formed. This mutation did not interfere with TAB1 binding to p38alpha. | 29229647 |
| 2018-09-01 11:27:00 | High TAB1 expression is associated with colorectal cancer. | 29328486 |
| Type | IDs |
|---|---|
| Synonymous | 3'-Tab1, MAP3K7IP1 |
| Gene |
UniProtKB-ID:
TAB1_HUMAN,
A8K6K3_HUMAN
UniprotKB:
Q15750,
A8K6K3
UniParc:
UPI0000136861,
UPI0000074095
EMBL:
U49928,
DQ314876,
AK291668,
AL022312,
Z83845,
AF425640,
CH471095,
AK312456,
BC050554
Ensembl:
ENSG00000100324
KO:
hsa:10454
|
| Nucleutide sequences |
EMBL-CDS:
ABC40735.1,
AAC12660.1,
AAH50554.1,
AAN32760.1,
EAW60326.1,
BAG35363.1,
BAF84357.1,
EAW60330.1
Gene_ORFName:
hCG_41717
Ensembl_TRS:
ENST00000216160,
ENST00000331454
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000216160,
ENSP00000333049
RefSeq:
NP_006107.1,
NP_705717.1
|
| Others |
UniRef100:
UniRef100_Q15750
UniRef90:
UniRef90_Q15750
UniRef50:
UniRef50_Q15750
UniGene:
Hs.507681,
Hs.729080
CCDS:
CCDS13993.1,
CCDS13992.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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