| Type | Description |
|---|---|
| Definition | IFI30 lysosomal thiol reductase |
| Date | Results | Publications |
|---|---|---|
| 2020-01-18 11:16:00 | GILT is a novel antiviral ISG that specifically inhibits the entry of selected enveloped RNA viruses in lysosomes via disruption of cathepsin L metabolism and function. | 31631785 |
| 2019-10-12 10:30:00 | GILT was highly expressed as observed in the public database on human gliomas and two human glioma cell lines, U373MG and U87MG cells. The downregulation of GILT by lentiviral-mediated silencing inhibits the cell growth, colony formation, and migration but promotes apoptosis and results in cell cycle arrest at the G0/G1 phase in the U373MG cells. | 30587343 |
| 2018-10-20 11:51:00 | Results shows that GILT expression is required for downregulation of PAX-3 proteins in late stage human melanoma cells. GILT co-localizes with PAX-3 proteins regulating its expression through the autophagy and lysosomal degradation pathway in human melanoma cells. | 28857256 |
| 2018-02-17 11:43:00 | GILT functions as a host restriction factor against the retroviruses. | 27655726 |
| 2017-01-14 11:40:00 | GILT expression is anticipated to result in improved presentation of melanoma antigens and more effective antimelanoma T-cell responses. | 26930048 |
| Type | IDs |
|---|---|
| Synonymous | GILT, IFI-30, IP-30, IP30 |
| Gene |
UniProtKB-ID:
GILT_HUMAN,
A0A024R7N7_HUMAN
UniprotKB:
P13284,
A0A024R7N7
UniParc:
UPI0000072A2B
EMBL:
CH471106,
AF097362,
AC068499,
AC093080,
AC007192,
AB049659,
BC031020,
J03909,
BC021136
Ensembl:
ENSG00000216490
KO:
hsa:10437
|
| Nucleutide sequences |
EMBL-CDS:
AAA36105.1,
AAH31020.1,
EAW84662.1,
AAF04618.1,
BAC98466.1,
AAH21136.1,
EAW84665.1
Gene_ORFName:
hCG_1777151
Ensembl_TRS:
ENST00000407280
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000384886
RefSeq:
NP_006323.2
|
| Others |
UniRef100:
UniRef100_P13284
UniRef90:
UniRef90_P13284
UniRef50:
UniRef50_P13284
UniGene:
Hs.14623
CCDS:
CCDS46015.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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