| Type | Description |
|---|---|
| Definition | insulin related protein 2 (islet 2) |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 11:10:00 | We demonstrate that mutation of a solvent exposed side chain in the spacer region of an LHX4-ISL2 complex has no significant effect on the structure of the complex, but decreases binding affinity, apparently by increasing flexibility of the linker. | 30788856 |
| 2015-08-15 10:23:00 | lack both Isl1 and Isl2, large numbers of motor neurons exited the neural tube, even prior to the appearance of boundary cap cells at the ventral exit points | 25843547 |
| 2012-03-31 10:05:00 | X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4.Isl2 complex exhibit many similarities with that of Lhx3.Isl1; structural differences supported by mutagenic studies reveal differences in the mechanisms of binding. | 22025611 |
| 2010-01-21 00:00:00 | Data describe how the dosage of LIM homeodomain proteins Isl1 and Isl2 and LIM-only protein Lmo4 influences the assembly and function of complexes involved in the generation of spinal motor neurons (MNs) and V2a interneurons (INs). | 19666821 |
| 2010-01-21 00:00:00 | Successful purification and crystallization of an engineered complex comprising the LIM domains of motor neuron protein Lhx4 and the Lim binding domain of Isl2 (islet 2 protein) are reported. | 19194008 |
| Type | IDs |
|---|---|
| Synonymous | 3110001N10Rik |
| Gene |
UniProtKB-ID:
ISL2_MOUSE,
Q0VAX2_MOUSE
UniprotKB:
Q9CXV0,
Q0VAX2
UniParc:
UPI0000DBDD60,
UPI0000023A43
EMBL:
BC120880,
BC148307,
AK013964,
CH466522,
AC116699
Ensembl:
ENSMUSG00000032318
KO:
mmu:104360
|
| Nucleutide sequences |
EMBL-CDS:
BAB29088.1,
EDL25854.1,
AAI20881.1,
AAI48308.2
Ensembl_TRS:
ENSMUST00000034869,
ENSMUST00000164373,
ENSMUST00000114290
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000034869,
ENSMUSP00000109929,
ENSMUSP00000130638
RefSeq:
XP_006510819.1,
NP_081673.2
|
| Others |
UniRef100:
UniRef100_Q9CXV0,
UniRef100_Q0VAX2
UniRef90:
UniRef90_Q0VAX2,
UniRef90_Q9CXV0
UniRef50:
UniRef50_P53406,
UniRef50_Q0VAX2
UniGene:
Mm.273996
CCDS:
CCDS23205.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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