| Type | Description |
|---|---|
| Definition | ariadne RBR E3 ubiquitin protein ligase 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-23 10:46:00 | Here, using a quantitative proteomics approach, the authors identify the E3 ligase ARIH2 as a regulator of the HIV-1 Vif protein-dependent CRL5-mediated APOBEC3 degradation. The CUL5(Vif/CBFss) complex recruits ARIH2 where it acts to transfer ubiquitin directly to the APOBEC3 targets. | 31253590 |
| 2019-05-04 11:40:00 | ubiquitin-associated (UBA) domain-containing DCNL1 is monoubiquitylated when bound to CRLs and that this monoubiquitylation depends on the CRL-associated Ariadne RBR ligases TRIAD1 (ARIH2) and HHARI (ARIH1) and strictly requires the DCNL1's UBA domain. | 30587576 |
| 2019-02-23 10:12:00 | Data found Mll-Ell increases Triad1 in a Hox-dependent manner. Triad1 antagonizes Mll-Ell-induced protein ubiquitination and progression to AML. Triad1 knockdown significantly shortened the latency to development of AML in mice transplanted with Mll-Ell-transduced bone marrow. Further results identify Triad1 as a leukemia suppressor in 11q23-AML. | 29459712 |
| 2017-11-25 15:57:00 | these findings reveal a novel mechanism of ubiquitination-dependent negative regulation of the NLRP3 inflammasome by ARIH2 and highlight ARIH2 as a potential therapeutic target for inflammatory diseases | 29021376 |
| 2014-12-06 12:21:00 | We show that ARIH2 E3-ligase regulates PABPN1 protein accumulation and aggregation | 24486325 |
| Type | IDs |
|---|---|
| Synonymous | ARI2, TRIAD1 |
| Gene |
UniProtKB-ID:
ARI2_HUMAN,
Q6IBL8_HUMAN,
Q53ET9_HUMAN
UniprotKB:
O95376,
Q6IBL8,
Q53ET9
UniParc:
UPI000050AA11,
UPI0000125EDA
EMBL:
CR456785,
AF183427,
AK223550,
AK313434,
CH471055,
BC000422,
AF099149,
AJ130978
Ensembl:
ENSG00000177479
KO:
hsa:10425
|
| Nucleutide sequences |
EMBL-CDS:
CAA10276.1,
AAC82469.1,
AAH00422.1,
AAG09696.1,
EAW64933.1,
CAG33066.1,
EAW64932.1,
EAW64930.1,
BAG36225.1,
BAD97270.1
Gene_ORFName:
HT005,
hCG_1779445
Ensembl_TRS:
ENST00000449376,
ENST00000356401
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000403222,
ENSP00000348769
RefSeq:
NP_001336146.1,
XP_024309077.1,
NP_001336152.1,
NP_001336139.1,
NP_001336157.1,
XP_024309078.1,
NP_001304263.1,
NP_001336159.1,
NP_001336149.1,
NP_001336154.1,
NP_001336143.1,
NP_001336142.1,
NP_001336155.1,
NP_001336147.1,
NP_001336153.1,
XP_016861023.1,
NP_001336148.1,
NP_001336158.1,
NP_001336144.1,
NP_001336138.1,
NP_001336140.1,
XP_016861025.1,
NP_001304262.1,
XP_016861024.1,
NP_001336150.1,
XP_011531578.1,
NP_001336151.1,
XP_011531575.1,
XP_011531570.1,
NP_001336145.1,
NP_001336141.1,
XP_024309076.1,
XP_011531573.1,
XP_011531569.1,
NP_006312.1,
XP_024309079.1,
NP_001336156.1,
XP_016861022.1
|
| Others |
UniRef100:
UniRef100_Q53ET9,
UniRef100_O95376
UniRef90:
UniRef90_O95376
UniRef50:
UniRef50_O95376
UniGene:
Hs.633601
CCDS:
CCDS2780.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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