| Type | Description |
|---|---|
| Definition | cytochrome P450, family 27, subfamily a, polypeptide 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 12:32:00 | High expression of cytochrome P450 family 27 subfamily A member 1 (CYP27A1), the enzyme responsible for the synthesis of 27-Hydroxycholesterol (27HC), is associated with decreased progression free survival for ovarian cancer. ID8 tumor cell grafts are unable to effectively establish in CYP27A1-/- mice, indicating involvement of the host environment. Tumors from mice treated with 27HC had altered myeloid cell composition. | 31048561 |
| 2020-02-22 12:07:00 | 7KCh up-regulated IL-1betamRNA, TNF-alphamRNA, IL-6 mRNA, and IL-1beta secretion of RPE. U0126, a MEK1/2 inhibitor, down regulated the expression of these inflammation factors. Our findings may help elucidate the potential role of 7KCh in the pathogenesis of AMD. | 31655042 |
| 2018-08-18 11:55:00 | In het mice, RIF had no effect on plasma lipids composition, CYP27A1 activity, and atherosclerotic plaque development, despite a reduction in cholesterol absorption. In conclusion, the antiatherogenic effect of Cyp3a11 induction by RIF was also dependent on Cyp27a1 expression. | 29191818 |
| 2017-06-24 10:10:00 | CYP46A1 is involved in cholestanol removal from the brain and that several factors contribute to the preferential increase in cholestanol in the cerebellum arising from CYP27A1 deficiency. | 28190002 |
| 2015-12-19 11:05:00 | The cholesterol diet reduced the levels of the "memory protein" Arc (Activity Regulated Cytoskeleton associated protein) in the hippocampus of the wildtype mice but not in the hippocampus of the Cyp27-/- mice. | 25453744 |
| Type | IDs |
|---|---|
| Synonymous | 1300013A03Rik, Cyp27 |
| Gene |
UniProtKB-ID:
CP27A_MOUSE
UniprotKB:
Q9DBG1
UniParc:
UPI0000022808
EMBL:
AK004977,
BC055028
Ensembl:
ENSMUSG00000026170
KO:
mmu:104086
|
| Nucleutide sequences |
EMBL-CDS:
BAB23713.1,
AAH55028.1
Ensembl_TRS:
ENSMUST00000027356
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027356
RefSeq:
XP_006495670.1,
NP_077226.2,
XP_036021544.1
|
| Others |
UniRef100:
UniRef100_Q9DBG1
UniRef90:
UniRef90_Q9DBG1
UniRef50:
UniRef50_Q02318
UniGene:
Mm.85083
CCDS:
CCDS15054.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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