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104 ADARB1

104

ADARB1

adenosine deaminase RNA specific B1

protein-coding

Homo sapiens

基因描述

Type Description
Definition adenosine deaminase RNA specific B1

研究结论

Date Results Publications
2020-09-26 13:08:00 Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. 32597966
2020-09-05 13:55:00 ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus. 31852792
2020-07-25 13:02:00 that the mislocalization of ADAR2 in C9orf72 mediated amyotrophic lateral sclerosis/frontotemporal dementia is responsible for the alteration of RNA processing events that may impact vast cellular functions 30945056
2020-07-18 12:04:00 We also observe a dominance of long-range interactions within ADAR substrates and analyze differences between ADAR1 and ADAR2 editing substrates. Moreover, we unexpectedly discovered that ADAR proteins bind dsRNA substrates tandemly in vivo, each with a 50-bp footprint. 32203492
2020-06-06 13:58:00 AKT-1, -2, and -3 interact with both ADAR1p110 and ADAR2 and phosphorylate these RNA editases. Using site-directed mutagenesis of suspected AKT phosphorylation sites, AKT was found to primarily phosphorylate ADAR1p110 and ADAR2 on T738 and T553, respectively, and overexpression of the phosphomimic mutants ADAR1p110 (T738D) and ADAR2 (T553D) resulted in a 50-100% reduction in editase activity. 31095429

名称对应

Type IDs
Synonymous ADAR2, DRABA2, DRADA2, RED1
Gene
UniProtKB-ID: RED1_HUMAN
UniprotKB: P78563
UniParc: UPI0000133622, UPI000002B233, UPI000056F12E, UPI0005A5D027, UPI00005B2F02, UPI000002B232
EMBL: U82120, AB194371, U82121, X99383, BX322560, AL163301, U76421, AB194372, AL133499, AF001042, X99227, U76422, FJ169506, U76420, CH471079, AB194370, BC065545, AB194373, AF533142, AP001579, AY135659, AF525422
Ensembl: ENSG00000197381
KO: hsa:104
Nucleutide sequences
EMBL-CDS: BAE16326.1, AAB58300.1, BAE16327.1, AAC51240.1, AAC51241.1, AAM83100.1, BAE16328.1, EAX09360.1, EAX09359.1, AAB61687.1, AAC51242.1, CAA67762.1, AAM97654.1, EAX09357.1, CAA67611.1, ACN49027.1, AAN10291.1, CAB90493.1, AAB61686.1, AAH65545.1, BAE16329.1
Ensembl_TRS: ENST00000360697, ENST00000496664, ENST00000437626, ENST00000492414, ENST00000629643, ENST00000348831, ENST00000389863
Protein sequencees
Ensembl_PRO: ENSP00000436367, ENSP00000374513, ENSP00000435381, ENSP00000353920, ENSP00000486475, ENSP00000015877, ENSP00000414600
RefSeq: XP_016883739.1, XP_016883744.1, XP_016883733.1, XP_016883736.1, NP_001103.1, XP_016883742.1, XP_016883734.1, NP_001333616.1, XP_016883743.1, XP_011527727.1, XP_016883738.1, XP_016883740.1, XP_016883732.1, XP_006724017.1, XP_016883735.1, NP_056648.1, XP_016883731.1, NP_001333617.1, NP_056649.1, XP_024307811.1, NP_001153702.1, XP_016883737.1, XP_011527734.1
Others
UniRef100: UniRef100_P78563
UniRef90: UniRef90_P78563
UniRef50: UniRef50_P78563
UniGene: Hs.474018
CCDS: CCDS33590.1, CCDS42970.1, CCDS33589.1

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