| Type | Description |
|---|---|
| Definition | ATPase phospholipid transporting 8A1 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 10:25:00 | cryo-electron microscopy structure of six intermediates of the human flippase ATP8A1 bound to the partner protein CDC50a; ATP binding and autophosphorylation of ATP8A1 drive a cycle of conformations in which lipids bind differently, powering translocation. | 31416931 |
| 2020-03-21 11:38:00 | ATP8A1 is cleaved by the cysteine protease calpain during apoptosis, and the cleavage is prevented indirectly by caspase inhibition, involving blockage of calcium influx into platelets and subsequent calpain activation. | 30674456 |
| 2019-05-18 10:59:00 | Single-nucleotide polymorphism, rs17448506, located in ATP8A1 intron, reached the significance threshold for interaction with tobacco smoke expose and bronchial hyperresponsiveness (p=10-5). | 30282721 |
| 2019-02-02 12:03:00 | Over-expression of ATP8A1 alleviated ethanol-induced hepatocyte injury. Moreover, the PI3K/Akt signaling pathway appears to participate in inhibition of ethanol-induced hepatocyte apoptosis. | 30457983 |
| 2019-02-02 11:16:00 | A pronounced induction of the flippase Atp8a1 was observed in post-mortem tissue homogenates from the hippocampus and temporal lobe of juvenile autistic subjects compared to age-matched controls. | 27287255 |
| Type | IDs |
|---|---|
| Synonymous | ATPASEII, ATPIA, ATPP2 |
| Gene |
UniProtKB-ID:
AT8A1_HUMAN
UniprotKB:
Q9Y2Q0
UniParc:
UPI00005DC772,
UPI000002A2FC,
UPI0000125063
EMBL:
AF067820,
AC139717,
AC110788,
AC084010,
CH471069,
AC096734,
BC109318,
BC109317,
AB013452
Ensembl:
ENSG00000124406
KO:
hsa:10396
|
| Nucleutide sequences |
EMBL-CDS:
AAI09318.1,
EAW93003.1,
AAY40980.1,
BAA77248.1,
AAY40924.1,
AAD34706.1,
AAI09319.1
Ensembl_TRS:
ENST00000381668,
ENST00000264449
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000371084,
ENSP00000264449
RefSeq:
NP_006086.1,
XP_016863136.1,
XP_016863135.1,
XP_011511918.1,
XP_011511920.1,
XP_011511917.1,
XP_016863134.1,
NP_001098999.1,
XP_005248100.1
|
| Others |
UniRef100:
UniRef100_Q9Y2Q0
UniRef90:
UniRef90_Q9Y2Q0
UniRef50:
UniRef50_Q9Y2Q0
UniGene:
Hs.435052
CCDS:
CCDS3466.1,
CCDS47049.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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