| Type | Description |
|---|---|
| Definition | mitochondrial calcium uptake 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:07:00 | The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter. | 32790952 |
| 2021-02-20 13:34:00 | Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2. | 32667285 |
| 2020-09-26 13:04:00 | Dysregulation of Mitochondrial Ca(2+) Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1. | 31665639 |
| 2020-04-25 12:08:00 | MICU1 confers Ca(2+)-dependent gating of the uniporter by blocking/unblocking MCU. | 30638448 |
| 2019-12-28 11:49:00 | Data show that phosphorylation at the N-terminal region of MICU1 leads to an increase in the basal mitochondrial Ca(2+) levels. A pool of active Akt in the mitochondria is responsible for MICU1 phosphorylation, and mitochondrion-targeted Akt strongly regulates the mitochondrial Ca(2+). The Akt-mediated phosphorylation impairs MICU1 processing and stability, culminating in production and tumor progression. | 30504268 |
| Type | IDs |
|---|---|
| Synonymous | CALC, CBARA1, EFHA3, MPXPS, ara CALC |
| Gene |
UniProtKB-ID:
MICU1_HUMAN
UniprotKB:
Q9BPX6
UniParc:
UPI000041AE90,
UPI0001AE6D99,
UPI0000E59246,
UPI00017A7236,
UPI0000035D9A
EMBL:
AK022697,
AL513185,
BC004190,
BC004216,
AK296086,
BC016641,
AK298347,
AL117423,
Y17711,
AK023318,
AC091769,
CH471083,
AL356009
Ensembl:
ENSG00000107745
KO:
hsa:10367
|
| Nucleutide sequences |
EMBL-CDS:
CAB55915.1,
BAG51182.1,
AAH16641.1,
EAW54459.1,
BAG60593.1,
BAB14187.1,
BAG58841.1,
AAH04190.1,
CAA76830.1,
AAH04216.1
Ensembl_TRS:
ENST00000361114,
ENST00000418483,
ENST00000398763
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000402470,
ENSP00000354415,
ENSP00000381747
RefSeq:
NP_006068.2,
XP_005269443.1,
NP_001182447.1,
NP_001182448.1,
NP_001350442.1,
XP_011537421.1
|
| Others |
UniRef100:
UniRef100_Q9BPX6
UniRef90:
UniRef90_Q9BPX6
UniRef50:
UniRef50_Q9BPX6
UniGene:
Hs.524367
CCDS:
CCDS55715.1,
CCDS55714.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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