| Type | Description |
|---|---|
| Definition | APC regulator of WNT signaling pathway 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 11:13:00 | findings identify APC2 as a radiographically distinguishable recessive form of lissencephaly | 31585108 |
| 2020-03-07 10:49:00 | Hsa_circ_0009361 acted as a tumor suppressive sponge of miR-582, which could up-regulate the expression of APC2, inhibit the Wnt/beta-catenin signaling, and suppress the growth and metastasis of colorectal cancer | 31109967 |
| 2020-02-01 12:16:00 | These results demonstrate that the circ-PKD2/miR-204-3p/APC2 axis represents a novel pathway involved in the pathogenesis of oral squamous cell carcinoma (OSCC) and may serve as a novel therapeutic target of OSCC. | 31206208 |
| 2019-07-06 10:31:00 | We have also identified a functionally important SUMO interacting motif in the cullin-homology domain of APC2 located near the APC4 sumoylation sites and APC/C catalytic core. Our findings provide evidence of an important regulatory role for SUMO modification and binding in affecting APC/C activation and mitotic exit. | 29517484 |
| 2019-03-30 10:05:00 | Results report that APC2 was hypermethylated in colorectal cancer (CRC) tissues and cell lines. An inverse correlation was observed between the APC2 methylation and its transcriptional levels. Furthermore, APC2_CPG_14 was an independent risk factor for overall survival in CRC patients. This study indicates that APC2 is hypermethylated and may be a tumorigenesis biomarker for Chinese CRC patients. | 30510602 |
| Type | IDs |
|---|---|
| Synonymous | APCL |
| Gene |
UniProtKB-ID:
APCL_HUMAN
UniprotKB:
O95996
UniParc:
UPI0000073D85,
UPI000059D61A,
UPI000162778E
EMBL:
AF110336,
AB022529,
CH471139,
AF110337,
BC032573,
AJ012652,
AF110335,
AF110334,
AB012162,
AJ131187,
AF128222
Ensembl:
ENSG00000115266
KO:
hsa:10297
|
| Nucleutide sequences |
EMBL-CDS:
CAA10317.1,
CAB61207.1,
AAH32573.1,
AAD29274.1,
BAA34611.1,
BAA75469.1,
EAW69498.1,
AAF01784.1,
AAD28183.1,
AAD29273.1
Ensembl_TRS:
ENST00000535453,
ENST00000233607
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000442954,
ENSP00000233607
RefSeq:
NP_005874.1,
XP_006722673.2,
XP_005259532.1,
XP_006722670.1,
NP_001338202.1,
XP_006722671.2,
XP_006722672.1
|
| Others |
UniRef100:
UniRef100_O95996
UniRef90:
UniRef90_O95996
UniRef50:
UniRef50_O95996
UniGene:
Hs.446376
CCDS:
CCDS12068.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员