| Type | Description |
|---|---|
| Definition | DnaJ heat shock protein family (Hsp40) member A2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:28:00 | Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles. | 33229560 |
| 2020-03-07 12:15:00 | overexpressing DNAJA2 but not DNAJA1 enhanced CFTR degradation at the endoplasmic reticulum by Hsc70/Hsp70 and the E3 ubiquitin ligase CHIP. Excess Hsp70 also promoted CFTR degradation, but this occurred through the lysosomal pathway and required CHIP but not complex formation with HOP and Hsp90. | 31408507 |
| 2020-01-11 10:41:00 | Study shows that Hsp40 and Hsp70 recognize a region of the androgen receptor (AR) N-terminal domain (NTD), including a FQNLF motif, that interacts with the AR ligand-binding domain (LBD) upon activation. This suggests that competition between molecular chaperones and the LBD for the FQNLF motif regulates AR activation. | 31395886 |
| 2014-03-22 11:21:00 | we combined the Hsp70-NEF pairs with cochaperones of the J protein family (DnaJA1, DnaJA2, DnaJB1, and DnaJB4) to generate 16 permutations. | 24318877 |
| 2013-02-16 11:29:00 | The DNAJA2 substrate release mechanism is essential for chaperone-mediated folding. | 23091061 |
| Type | IDs |
|---|---|
| Synonymous | CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2 |
| Gene |
UniProtKB-ID:
DNJA2_HUMAN,
A0A024R6S1_HUMAN
UniprotKB:
O60884,
A0A024R6S1
UniParc:
UPI0000052A4E
EMBL:
AJ001309,
BC015809,
AK313031,
Y13350,
BC013044,
CH471092,
AF011793
Ensembl:
ENSG00000069345
KO:
hsa:10294
|
| Nucleutide sequences |
EMBL-CDS:
CAA04669.1,
CAA73791.1,
AAH15809.1,
AAH13044.1,
AAB69313.1,
EAW82693.1,
BAG35864.1,
EAW82694.1
Gene_ORFName:
hCG_21797
Ensembl_TRS:
ENST00000317089
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000314030
RefSeq:
NP_005871.1
|
| Others |
UniRef100:
UniRef100_O60884
UniRef90:
UniRef90_O60884
UniRef50:
UniRef50_O60884
UniGene:
Hs.368078
CCDS:
CCDS10726.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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