| Type | Description |
|---|---|
| Definition | sprouty RTK signaling antagonist 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:33:00 | Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3beta-mediated restriction of epithelial IL-33. | 33547321 |
| 2020-08-22 15:30:00 | Spatial signal repression as an additional role of Sprouty2 protein variants. | 31154002 |
| 2020-02-15 13:03:00 | CASC2 competes with SPRY2 for miR-183 binding to rescue the expression of SPRY2 in PC cells, thus enhancing the sensitivity of PC cells to docetaxel through SPRY2 downstream ERK signaling pathway | 29373811 |
| 2019-12-28 11:03:00 | The findings present the first evidence indicating that miR-23b can promote the proliferation, migration, and EMT of LECs by targeting SPRY2 and the inhibition of miR-23b may possess the therapeutic potential for cataract. | 31235073 |
| 2019-12-14 10:49:00 | SPRY2 was correlated with favourable prognosis of intrahepatic cholangiocarcinoma (ICC) via suppressing FGFR2-induced ERK phosphorylation, invasion and EMT. The phosphorylation of SPRY2-Y55 was required in this tumour-suppressing function of SPRY2. | 30160357 |
| Type | IDs |
|---|---|
| Synonymous | IGAN3, hSPRY2 |
| Gene |
UniProtKB-ID:
SPY2_HUMAN
UniprotKB:
O43597
UniParc:
UPI0000001301
EMBL:
AL354668,
AK313810,
BC015745,
AL713749,
AF039843
Ensembl:
ENSG00000136158
KO:
hsa:10253
|
| Nucleutide sequences |
EMBL-CDS:
BAG36546.1,
AAH15745.1,
AAC04258.1,
CAD28524.1
Ensembl_TRS:
ENST00000377102,
ENST00000377104
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000366306,
ENSP00000366308
RefSeq:
NP_001305467.1,
NP_001305465.1,
NP_001305466.1,
NP_005833.1
|
| Others |
UniRef100:
UniRef100_O43597
UniRef90:
UniRef90_O43597
UniRef50:
UniRef50_O43597
UniGene:
Hs.18676
CCDS:
CCDS9463.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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