| Type | Description |
|---|---|
| Definition | histone H4 transcription factor |
| Date | Results | Publications |
|---|---|---|
| 2017-08-19 12:21:00 | Induction of Hinfp begins at the 4-cell stage. Maternally encoded Hinfp sustains development of pre-implantation stage embryos. Hinfp loss delays growth of blastocyst stage embryos that later fail to implant. Hinfp ablation severely reduces histone H4 mRNA and causes DNA damage. Transmission of maternal Hinfp transcripts and zygotic activation of the Hinfp gene together are neeeded to control early H4 gene expression. | 27609454 |
| 2016-05-21 10:54:00 | simultaneous loss of both Hinfp and the p53 checkpoint is detrimental to normal cell growth and may predispose to cellular transformation. | 26030398 |
| 2014-12-20 10:06:00 | Data show that conditional ablation of HINFP compromises cell proliferation, impairs DNA synthesis, alters nucleosome spacing and increases double-stranded DNA damage. | 24797072 |
| 2011-10-01 12:08:00 | The in vivo co-expression of Hinfp and histone H4 genes is consistent with the biological function of Hinfp as a principal transcriptional regulator of histone H4 gene expression during mouse development. | 21605641 |
| 2010-01-21 00:00:00 | Data indicate that the CDK2/cyclin E/p220(NPAT)/HINFP/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis. | 19590016 |
| Type | IDs |
|---|---|
| Synonymous | AA589481, HiNF-P, Mizf |
| Gene |
UniProtKB-ID:
HINFP_MOUSE
UniprotKB:
Q8K1K9
UniParc:
UPI00001932C3
EMBL:
AC124577,
BC029091,
AK049633
Ensembl:
ENSMUSG00000032119
KO:
mmu:102423
|
| Nucleutide sequences |
EMBL-CDS:
BAC33849.1,
AAH29091.1
Ensembl_TRS:
ENSMUST00000216508
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000149879
RefSeq:
XP_036010397.1,
XP_036010396.1,
NP_751894.2,
XP_006509962.1,
XP_011240681.1,
XP_011240679.1,
XP_030099795.1,
XP_030099794.1,
XP_011240680.1,
XP_036010395.1,
XP_006509960.1,
XP_030099793.1,
XP_011240678.1
|
| Others |
UniRef100:
UniRef100_Q8K1K9
UniRef90:
UniRef90_Q8K1K9
UniRef50:
UniRef50_Q8K1K9
UniGene:
Mm.24570
CCDS:
CCDS23102.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员