| Type | Description |
|---|---|
| Definition | calcium binding and coiled-coil domain 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:28:00 | The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment. | 32773036 |
| 2020-10-03 10:43:00 | The CALCOCO2, but not SQSTM1, suppresses the antiviral type I interferon signaling by promoting autophagy-mediated degradation of the mitochondrial antiviral signaling (MAVS) protein. | 30154446 |
| 2020-01-18 11:10:00 | The altered expression of NRBP2 and CALCOCO2 is associated with left ventricular dysfunction parameters in human dilated cardiomyopathy. | 31009519 |
| 2019-10-19 12:19:00 | The capability of NDP52 to induce mitophagy is dependent on its interaction with the FIP200/ULK1 complex, which is facilitated by TBK1. Ectopically tethering ULK1 to cargo bypasses the requirement for autophagy receptors and TBK1. | 30853401 |
| 2019-10-19 10:23:00 | we show that, essential for anti-bacterial autophagy, the cargo receptor NDP52 forms a trimeric complex with FIP200 and SINTBAD/NAP1, which are subunits of the autophagy-initiating ULK and the TBK1 kinase complex, respectively. FIP200 and SINTBAD/NAP1 are each recruited independently to bacteria via NDP52, as revealed by selective point mutations in their respective binding sites | 30853402 |
| Type | IDs |
|---|---|
| Synonymous | NDP52 |
| Gene |
UniProtKB-ID:
CACO2_HUMAN
UniprotKB:
Q13137
UniParc:
UPI0001AE671A,
UPI000006F8E3,
UPI0001D3B720,
UPI00017A7779,
UPI0001D3B723
EMBL:
AK293137,
CR456763,
AK222666,
BC004130,
AK314796,
U22897,
AK293329,
AK223227,
BC015893,
AC068531,
AK303313,
CH471109,
AK298177
Ensembl:
ENSG00000136436
KO:
hsa:10241
|
| Nucleutide sequences |
EMBL-CDS:
BAD96947.1,
BAG56845.1,
BAG56685.1,
CAG33044.1,
BAG37327.1,
AAA75297.1,
AAH15893.1,
BAG60448.1,
BAD96386.1,
EAW94707.1,
AAH04130.1,
BAG64382.1
Ensembl_TRS:
ENST00000509507,
ENST00000258947,
ENST00000508679,
ENST00000448105,
ENST00000416445
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000258947,
ENSP00000398523,
ENSP00000424352,
ENSP00000423437,
ENSP00000406974
RefSeq:
NP_001248324.1,
NP_005822.1,
NP_001248319.1,
NP_001248322.1,
NP_001248320.1
|
| Others |
UniRef100:
UniRef100_Q13137
UniRef90:
UniRef90_Q13137
UniRef50:
UniRef50_Q13137
UniGene:
Hs.514920
CCDS:
CCDS58560.1,
CCDS11538.1,
CCDS58558.1,
CCDS58561.1,
CCDS58559.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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