| Type | Description |
|---|---|
| Definition | CD96 molecule |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:30:00 | CD96, a new immune checkpoint, correlates with immune profile and clinical outcome of glioma. | 32612110 |
| 2020-12-12 13:24:00 | CD96 functions as a co-stimulatory receptor to enhance CD8(+) T cell activation and effector responses. | 32043568 |
| 2020-06-27 11:42:00 | increased expression on intratumoral natural killer cells of hepatocellular carcinoma patients | 30411378 |
| 2020-03-28 10:22:00 | Results show that the first immunoglobulin domain (D1) of CD96 is sufficient to mediate a robust interaction with necl-5, but not the DNAM-1 and TIGIT ligand, nectin-2. The crystal structure of CD96-D1 bound to the necl-5 ectodomain revealed that CD96 recognized necl-5 D1 via a conserved "lock-and-key" interaction observed across TIGIT:necl complexes. | 30528596 |
| 2020-01-18 10:43:00 | CD96 expression was highly correlated with T-cell markers in primary and metastatic human tumors and was elevated on antigen-experienced T cells and tumor-infiltrating lymphocytes. Collectively, these data demonstrate that CD96 may be a promising immune checkpoint to enhance T-cell function against human cancer and infectious disease | 30222899 |
| Type | IDs |
|---|---|
| Synonymous | TACTILE |
| Gene |
UniProtKB-ID:
TACT_HUMAN,
Q8WUE2_HUMAN,
E9PEJ1_HUMAN
UniprotKB:
P40200,
Q8WUE2,
E9PEJ1
UniParc:
UPI00000737A9,
UPI000013686B,
UPI000013DD36,
UPI0000209F1F
EMBL:
M88282,
AC092916,
CH471052,
AC074277,
BC020749,
AC055748,
AL833681
Ensembl:
ENSG00000153283
KO:
hsa:10225
|
| Nucleutide sequences |
EMBL-CDS:
AAA36662.1,
CAI46155.1,
EAW79698.1,
EAW79697.1,
AAH20749.1
Gene_ORFName:
hCG_26934
Ensembl_TRS:
ENST00000352690,
ENST00000283285,
ENST00000438817,
ENST00000494798
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000342040,
ENSP00000283285,
ENSP00000389801,
ENSP00000417152
RefSeq:
NP_001305818.1,
NP_005807.1,
XP_016861011.1,
NP_937839.1,
XP_016861010.1,
XP_005247120.1,
XP_006713532.1,
XP_006713533.1
|
| Others |
UniRef100:
UniRef100_P40200,
UniRef100_Q8WUE2,
UniRef100_E9PEJ1
UniRef90:
UniRef90_P40200,
UniRef90_A0A2R9BSE9
UniRef50:
UniRef50_P40200,
UniRef50_A0A2R9BSE9
UniGene:
Hs.142023
CCDS:
CCDS2958.1,
CCDS2959.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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