| Type | Description |
|---|---|
| Definition | tyrosine kinase non receptor 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:48:00 | Knockdown of activated Cdc42-associated kinase inhibits human extravillous trophoblast migration and invasion and decreases protein expression of pho-Akt and matrix metalloproteinase. | 30282494 |
| 2020-11-21 13:13:00 | Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen. | 31819114 |
| 2020-05-09 10:37:00 | Together, these data support a model wherein TNK2, WASL, and NCK1 comprise a pathway important for the entry of multiple picornaviruses. | 31769754 |
| 2020-04-11 11:05:00 | in this review, we will be summarizing the structural characteristics, activation, and regulation of ACK1 in breast cancer, aiming to deeply understand the functional and mechanistic role of ACK1 and provide novel therapeutic strategies for breast cancer treatment. | 31772931 |
| 2019-11-09 10:43:00 | ACK1 activated AKT and Src enhanced nuclear factor-small ka, CyrillicB (NF-small ka, CyrillicB) activity, suggesting a correlation between NF-small ka, CyrillicB signaling and TNF-alpha-mediated apoptosis in Caco-2 cells. Results demonstrate that ACK1 plays an important role in modulating TNF-alpha-induced aberrant cell proliferation and apoptosis, mediated in part by ACK1 activation. | 28921811 |
| Type | IDs |
|---|---|
| Synonymous | ACK, ACK-1, ACK1, p21cdc42Hs |
| Gene |
UniProtKB-ID:
ACK1_HUMAN,
B3KXJ4_HUMAN,
A0A5F9ZGX5_HUMAN,
C9J1X3_HUMAN,
A0A5F9ZHJ2_HUMAN,
A0A499FJ16_HUMAN
UniprotKB:
Q07912,
B3KXJ4,
A0A5F9ZGX5,
C9J1X3,
A0A5F9ZHJ2,
A0A499FJ16
UniParc:
UPI000021D19E,
UPI00004A2854,
UPI000006E4CB,
UPI0007DC72E6,
UPI0010696220,
UPI00004C9B08,
UPI000387BC13,
UPI0001639B40
EMBL:
AK127455,
L13738,
BC028164,
AC124944,
BC008884,
AK131539
Ensembl:
ENSG00000061938
KO:
hsa:10188
|
| Nucleutide sequences |
EMBL-CDS:
AAA53570.2,
AAH28164.1,
AAH08884.1,
BAD18675.1,
BAG54506.1
Ensembl_TRS:
ENST00000671753,
ENST00000439230,
ENST00000333602,
ENST00000672887,
ENST00000428187,
ENST00000673038,
ENST00000381916
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000499858,
ENSP00000329425,
ENSP00000395588,
ENSP00000499899,
ENSP00000392546,
ENSP00000500452,
ENSP00000371341
RefSeq:
NP_001374638.1,
NP_001374641.1,
NP_001010938.2,
NP_001374645.1,
NP_005772.3,
NP_001374649.1,
NP_001369201.1,
NP_001369204.1,
XP_011510619.1,
NP_001374650.1,
XP_011510620.2,
NP_001374643.1,
XP_005269332.1,
XP_024309059.1,
NP_001369200.1,
XP_024309061.1,
XP_016860998.1,
NP_001374648.1,
NP_001374647.1,
NP_001374636.1,
NP_001369202.1,
XP_024309060.1,
NP_001374639.1,
NP_001374640.1,
NP_001369203.1,
NP_001374637.1,
XP_024309063.1,
XP_024309062.1,
NP_001374646.1,
NP_001374642.1,
XP_011510623.1,
XP_005269331.1,
NP_001294975.1,
NP_001373093.1,
NP_001374644.1
|
| Others |
UniRef100:
UniRef100_Q07912,
UniRef100_C9J1X3,
UniRef100_A0A499FJ16,
UniRef100_A0A5F9ZGX5,
UniRef100_A0A5F9ZHJ2
UniRef90:
UniRef90_Q07912,
UniRef90_C9J1X3,
UniRef90_A0A5F9ZHJ2,
UniRef90_A0A2I3TMU8
UniRef50:
UniRef50_Q07912,
UniRef50_O54967-3
UniGene:
Hs.518513
CCDS:
CCDS33927.1,
CCDS33928.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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