| Type | Description |
|---|---|
| Definition | adhesion G protein-coupled receptor G2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:57:00 | A novel hemizygous loss-of-function mutation in ADGRG2 causes male infertility with congenital bilateral absence of the vas deferens. | 32314195 |
| 2020-05-09 11:24:00 | data suggest that GPCR64 N-terminal fragment not only shields the tethered agonist to prevent G protein signaling but also confers a conformation that inhibits the interaction with beta-arrestins and the consequent endocytosis and sustained signaling from endosomes | 31502283 |
| 2020-01-11 10:03:00 | G-protein coupled receptor 64 (GPR64) levels are remarkably lower in endometrial carcinoma samples compared to control. Depletion of GPR64 reveals an increase of colony formation ability, cell proliferation, cell migration, and invasion activity in Ishikawa and HEC1A cells. The expression of Connexin 43 is reduced through activation of AMP-activated protein kinase in tumor cells with GPR64-deficiency. | 31412816 |
| 2019-11-30 11:59:00 | Study identified novel nonsense variant c.2440C > T(p.Arg814*) in X-linked gene ADGRG2 as cause of obstructive azoospermia in a large Pakistani family. | 30389958 |
| 2019-01-19 10:47:00 | The expression of GPR64 was increased in human endometrial stromal cells (hESCs) during in vitro decidualization. Interestingly, siRNA-mediated knockdown of GPR64 in hESCs remarkably reduced decidualization. These results suggest that Gpr64 has a crucial role in the decidualization of endometrial stromal cells. | 28694502 |
| Type | IDs |
|---|---|
| Synonymous | CBAVDX, EDDM6, GPR64, HE6, TM7LN2 |
| Gene |
UniProtKB-ID:
AGRG2_HUMAN,
Q499H0_HUMAN,
A8K4P7_HUMAN
UniprotKB:
Q8IZP9,
Q499H0,
A8K4P7
UniParc:
UPI0000DA6BD9,
UPI00004A3B15,
UPI00019B21FE,
UPI00005725B3,
UPI000021246C,
UPI0000EC7F53,
UPI00001AEF0D,
UPI00019B21FF,
UPI00015DA682,
UPI0000212471,
UPI00004A3B17,
UPI00004A3B16
EMBL:
AK291012,
BC099901,
AF538954,
AY143366,
AY143364,
AL732509,
BC113979,
AY143367,
AF539455,
AL732578,
AY143365,
AY148343,
AF539456,
X81892
Ensembl:
ENSG00000173698
KO:
hsa:10149
|
| Nucleutide sequences |
EMBL-CDS:
AAI13980.1,
AAN38971.1,
AAN33056.1,
AAN38973.1,
AAN75702.1,
AAN38974.1,
AAN38972.1,
CAA57479.1,
AAN33065.1,
AAN33064.1,
AAH99901.1,
BAF83701.1
Ensembl_TRS:
ENST00000357991,
ENST00000354791,
ENST00000379869,
ENST00000360279,
ENST00000357544,
ENST00000379878,
ENST00000379873,
ENST00000340581,
ENST00000356606,
ENST00000379876
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000350680,
ENSP00000350152,
ENSP00000346845,
ENSP00000344972,
ENSP00000369207,
ENSP00000369202,
ENSP00000349015,
ENSP00000369198,
ENSP00000369205,
ENSP00000353421
RefSeq:
XP_011543737.1,
NP_001171765.1,
NP_001171763.1,
NP_001073329.1,
NP_005747.2,
NP_001171762.1,
XP_006724518.1,
XP_011543736.1,
NP_001073328.1,
NP_001073327.1,
NP_001171766.1,
NP_001171764.1
|
| Others |
UniRef100:
UniRef100_Q499H0,
UniRef100_A8K4P7,
UniRef100_Q8IZP9
UniRef90:
UniRef90_Q8IZP9
UniRef50:
UniRef50_Q8IZP9
UniGene:
Hs.146978
CCDS:
CCDS14191.1,
CCDS43923.1,
CCDS43922.1,
CCDS55376.1,
CCDS55379.1,
CCDS55377.1,
CCDS43921.1,
CCDS55378.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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