| Type | Description |
|---|---|
| Definition | protection of telomeres 1A |
| Date | Results | Publications |
|---|---|---|
| 2019-04-13 11:44:00 | nearly identical POT1b subunit of shelterin has been shown to be much less proficient than POT1a in repression of ATR | 30082315 |
| 2018-02-03 11:16:00 | The telomere binding protein POT1a inhibits the production of reactive oxygen species, and rejuvenates aged hematopoietic stem cells. | 28986560 |
| 2017-09-23 10:11:00 | proliferation of cancer cells lacking POT1 is enabled by the attenuation of the ATR kinase pathway. | 27239034 |
| 2017-07-01 12:33:00 | Lung fibroblasts deficient in Sirt1 or treated with a selective Sirt1 inhibitor exhibit increased cellular senescence and decreased TPP1 levels, whereas Sirt1 overexpression and pharmacological activation protect against CS-induced TPP1 reduction and telomeric DNA damage. | 27559927 |
| 2015-01-24 11:49:00 | demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 phenocopy the POT1a,b knockout setting without showing additional phenotypes | 25056954 |
| Type | IDs |
|---|---|
| Synonymous | 1500031H18Rik, AI851169, Pot1 |
| Gene |
UniProtKB-ID:
POTE1_MOUSE
UniprotKB:
Q91WC1
UniParc:
UPI000002936D,
UPI00000EAA2F
EMBL:
BC016121,
AK085041,
AK036052,
AK040864
Ensembl:
ENSMUSG00000029676
KO:
mmu:101185
|
| Nucleutide sequences |
EMBL-CDS:
BAC30723.1,
BAC29288.1,
AAH16121.1,
BAC39349.1
Ensembl_TRS:
ENSMUST00000166445,
ENSMUST00000115330
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000131928,
ENSMUSP00000110986
RefSeq:
XP_006505019.1,
XP_006505018.1,
NP_598692.1
|
| Others |
UniRef100:
UniRef100_Q91WC1
UniRef90:
UniRef90_Q91WC1
UniRef50:
UniRef50_Q9NUX5-2
UniGene:
Mm.274589,
Mm.397208
CCDS:
CCDS39442.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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