App - amyloid beta precursor protein-BMKCloudï½ç¾è¿å®¢äº

100689222 App

基因描述

Type	Description
Definition	amyloid beta precursor protein

研究结论

Date	Results	Publications
2014-02-06 16:53:00	Over-expression of wild-type AbetaPP is sufficient to induce mitochondrial oxidative stress and intrinsic apoptosis, suggesting a pro-oxidant role for AbetaPP at mitochondria which may be relevant in Alzheimer's disease.	22133762

名称对应

Type	IDs
Synonymous	Abpp
Gene
Nucleutide sequences
Protein sequencees	RefSeq: XP_007643505.1, XP_027268167.1, XP_027268168.1, XP_027268169.1, XP_027268162.1, XP_027268163.1, XP_027268164.1
Others

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{{proteinIndex+1}}	mRNA	Protein	UniprotKB	Description
Refseq	{{protein.nucleotideVersion}} Ensembl: {{protein.nucleotideEnsembl}}	{{protein.proteinVersion}} Ensembl: {{protein.proteinEnsembl}}	{{uniprot}}	Definition: {{{protein.definition}}} Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}}
Location	( {{protein.positionStart}}..{{protein.positionEnd}} )
Conserved domain	Region: {{conservedDomain.region == '' \|\| conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' \|\| conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' \|\| conservedDomain.family == null ? "-": conservedDomain.family}} CDD:	{{conservedDomain.comments == '' \|\| conservedDomain.comments == null ? "-" : conservedDomain.comments }}	Region: {{conservedDomain.region == '' \|\| conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' \|\| conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' \|\| conservedDomain.family == null ? "-": conservedDomain.family}} CDD:	{{conservedDomain.comments == '' \|\| conservedDomain.comments == null ? "-" : conservedDomain.comments }}

mRNA

Protein

UniprotKB

Description

Refseq

Ensembl: {{protein.nucleotideEnsembl}}

Ensembl: {{protein.proteinEnsembl}}

Definition: {{{protein.definition}}}

Transcript Veriant:{{protein.transcriptVeriant}}

Status: {{protein.status}}

Location

( {{protein.positionStart}}..{{protein.positionEnd}} )

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Pubmed编号	文献信息	发表日期	相关基因
22133762	Overexpression of amyloid-Î² protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade. J. Alzheimers Dis. Matthew G Bartley , Kristin Marquardt , Danielle Kirchhof , Heather M Wilkins , David Patterson , Daniel A Linseman	2012-01-01	App
21945585	Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. J. Biotechnol. Jennifer Becker , Matthias Hackl , Oliver Rupp , Tobias Jakobi , Jessica Schneider , Rafael Szczepanowski , Thomas Bekel , Nicole Borth , Alexander Goesmann , Johannes Grillari , Christian Kaltschmidt , Thomas Noll , Alfred PÃ¼hler , Andreas Tauch , Karina Brinkrolf	2011-12-10	Tp53, Tuba1b, Mgat1, Plec, Kif23, Manea, Abcb1a, Abcb1b, Ahr, Slc35c2, Adam17, LOC100689011, Polr2a, Srebf2, Cbr3, Slc20a2, LOC100689024, Slc20a1, Ubtf, Dhfr, Lpin1, Slc35b4, Bax, Col4a3bp, Cdk2, Hspg2, Orc5, Orc4, Ercc4, Top1, Scap, Adapt15, Eef2, Myl6, Rps17, Dpagt1, Lrrfip1, Ncl, Sdc1, Rps2, Adsl, Casp3, Xbp1, Ccnd1, Ldha, Gna11, Gnas, Gnai2, Gnao1, Gna13, Gnai3, Cirbp, Gja1, Rad51c, Insig2, Insig1, Xpr1, Mbtps2, Srsf1, Tubb, Tubb4b, Bst2, Pisd, Slc31a1, Dnase1l1, Calr, Creld2, Mogs, Vim, Cxcl3, Ctps1, Fth1, Ssb, Sumo2, Akr1a1, Cdkn1a, Slc7a1, Pam16, Tlr6, Il6, St3gal3, Slc38a2, Gnat1, Lpl, Fdft1, Sars, Xpa, Brca2, Acox1, Ddrgk1, Gls, Psmc3, Srrt, Trpc1, Fasn, Abcc1, St8sia4, Trpc2, Klc1
15126508	The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. J Biol Chem Judy A Cam , Celina V Zerbinatti , Jane M Knisely , Silva Hecimovic , Yonghe Li , Guojun Bu	2004-07-09	-

Pubmed编号

文献信息

发表日期

相关基因

22133762

Overexpression of amyloid-Î² protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade.

J. Alzheimers Dis. Matthew G Bartley , Kristin Marquardt , Danielle Kirchhof , Heather M Wilkins , David Patterson , Daniel A Linseman

2012-01-01

App

21945585

Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.

J. Biotechnol. Jennifer Becker , Matthias Hackl , Oliver Rupp , Tobias Jakobi , Jessica Schneider , Rafael Szczepanowski , Thomas Bekel , Nicole Borth , Alexander Goesmann , Johannes Grillari , Christian Kaltschmidt , Thomas Noll , Alfred PÃ¼hler , Andreas Tauch , Karina Brinkrolf

2011-12-10

Tp53, Tuba1b, Mgat1, Plec, Kif23, Manea, Abcb1a, Abcb1b, Ahr, Slc35c2, Adam17, LOC100689011, Polr2a, Srebf2, Cbr3, Slc20a2, LOC100689024, Slc20a1, Ubtf, Dhfr, Lpin1, Slc35b4, Bax, Col4a3bp, Cdk2, Hspg2, Orc5, Orc4, Ercc4, Top1, Scap, Adapt15, Eef2, Myl6, Rps17, Dpagt1, Lrrfip1, Ncl, Sdc1, Rps2, Adsl, Casp3, Xbp1, Ccnd1, Ldha, Gna11, Gnas, Gnai2, Gnao1, Gna13, Gnai3, Cirbp, Gja1, Rad51c, Insig2, Insig1, Xpr1, Mbtps2, Srsf1, Tubb, Tubb4b, Bst2, Pisd, Slc31a1, Dnase1l1, Calr, Creld2, Mogs, Vim, Cxcl3, Ctps1, Fth1, Ssb, Sumo2, Akr1a1, Cdkn1a, Slc7a1, Pam16, Tlr6, Il6, St3gal3, Slc38a2, Gnat1, Lpl, Fdft1, Sars, Xpa, Brca2, Acox1, Ddrgk1, Gls, Psmc3, Srrt, Trpc1, Fasn, Abcc1, St8sia4, Trpc2, Klc1

15126508

The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.

J Biol Chem Judy A Cam , Celina V Zerbinatti , Jane M Knisely , Silva Hecimovic , Yonghe Li , Guojun Bu

2004-07-09

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