Scap - SREBF chaperone-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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100689048 Scap

基因描述

Type	Description
Definition	SREBF chaperone

研究结论

Date	Results	Publications
2016-12-17 10:40:00	Data indicate that scap protein Loop1, when expresses alone, remained intracellular and membrane-bound, but when Loop7 was co-expressed, it bound to Loop1, and the soluble complex was secreted.	27068746

名称对应

Type	IDs
Gene	UniProtKB-ID: SCAP_CRIGR UniprotKB: P97260 UniParc: UPI0000135623 EMBL: AF541996, U67060 KO: cge:100689048
Nucleutide sequences	EMBL-CDS: AAQ11376.1, AAB19103.1
Protein sequencees	RefSeq: NP_001230965.1
Others	UniRef100: UniRef100_P97260 UniRef90: UniRef90_P97260 UniRef50: UniRef50_P97260

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
27068746	Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS. J Biol Chem Yinxin Zhang , Kwang Min Lee , Lisa N Kinch , Lindsay Clark , Nick V Grishin , Daniel M Rosenbaum , Michael S Brown , Joseph L Goldstein , Arun Radhakrishnan	2016-06-10	-
24217618	Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis. J Cell Biol Michael D Huber , Paul W Vesely , Kaustuv Datta , Larry Gerace	2013-11-11	-
21945585	Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. J. Biotechnol. Jennifer Becker , Matthias Hackl , Oliver Rupp , Tobias Jakobi , Jessica Schneider , Rafael Szczepanowski , Thomas Bekel , Nicole Borth , Alexander Goesmann , Johannes Grillari , Christian Kaltschmidt , Thomas Noll , Alfred PÃ¼hler , Andreas Tauch , Karina Brinkrolf	2011-12-10	Tp53, Tuba1b, Mgat1, Plec, Kif23, Manea, Abcb1a, Abcb1b, Ahr, Slc35c2, Adam17, LOC100689011, Polr2a, Srebf2, Cbr3, Slc20a2, LOC100689024, Slc20a1, Ubtf, Dhfr, Lpin1, Slc35b4, Bax, Col4a3bp, Cdk2, Hspg2, Orc5, Orc4, Ercc4, Top1, Scap, Adapt15, Eef2, Myl6, Rps17, Dpagt1, Lrrfip1, Ncl, Sdc1, Rps2, Adsl, Casp3, Xbp1, Ccnd1, Ldha, Gna11, Gnas, Gnai2, Gnao1, Gna13, Gnai3, Cirbp, Gja1, Rad51c, Insig2, Insig1, Xpr1, Mbtps2, Srsf1, Tubb, Tubb4b, Bst2, Pisd, Slc31a1, Dnase1l1, Calr, Creld2, Mogs, Vim, Cxcl3, Ctps1, Fth1, Ssb, Sumo2, Akr1a1, Cdkn1a, Slc7a1, Pam16, Tlr6, Il6, St3gal3, Slc38a2, Gnat1, Lpl, Fdft1, Sars, Xpa, Brca2, Acox1, Ddrgk1, Gls, Psmc3, Srrt, Trpc1, Fasn, Abcc1, St8sia4, Trpc2, Klc1
17428919	Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proc. Natl. Acad. Sci. U.S.A. Li-Ping Sun , Joachim Seemann , Joseph L Goldstein , Michael S Brown	2007-04-17	Scap
17428920	Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proc. Natl. Acad. Sci. U.S.A. Arun Radhakrishnan , Yukio Ikeda , Hyock Joo Kwon , Michael S Brown , Joseph L Goldstein	2007-04-17	INSIG2
15899885	Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. J Biol Chem Li-Ping Sun , Lu Li , Joseph L Goldstein , Michael S Brown	2005-07-15	-
15728349	Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change. Proc. Natl. Acad. Sci. U.S.A. Jamison D Feramisco , Arun Radhakrishnan , Yukio Ikeda , Julian Reitz , Michael S Brown , Joseph L Goldstein	2005-03-01	Scap
15260976	Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Mol. Cell Arun Radhakrishnan , Li-Ping Sun , Hyock Joo Kwon , Michael S Brown , Joseph L Goldstein	2004-07-23	-
12482938	Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols. Proc. Natl. Acad. Sci. U.S.A. Daisuke Yabe , Zong-Ping Xia , Christopher M Adams , Robert B Rawson	2002-12-24	Scap, SCAP, INSIG1, INSIG2
12193656	Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER. Proc. Natl. Acad. Sci. U.S.A. Peter J Espenshade , Wei-Ping Li , Daisuke Yabe	2002-09-03	Scap, Sec23a

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