| Type | Description |
|---|---|
| Definition | spondin 2, extracellular matrix protein |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 11:04:00 | mindin binds with the integrin Mac-1 to promote macrophage phagocytosis through Syk activation and NF-kappaB p65 translocation. | 30869196 |
| 2020-05-16 12:23:00 | Study identified the extracelular matrix protein mindin in the secretome of prostate adenocarcinoma cells and show that mindin overexpression in human and mouse TRAMP-C1-induced prostate tumors correlates with upregulated levels of bone-related genes in the tumorigenic prostate tissues. Mindin silencing decreased osteomimicry in adenocarcinoma cells and in the prostate tumor mice model. | 31168562 |
| 2016-12-17 11:54:00 | Mindin is a novel modulator of hepatic I/R injury through regulating inflammatory responses, as well as hepatocyte apoptosis and proliferation via inactivation of the Akt signaling pathway. | 26165142 |
| 2015-07-25 11:10:00 | Mindin protects against vascular hyperplasia by suppression of abnormal VSMC proliferation, migration and phenotypic switching in an AKT-dependent manner. | 25751394 |
| 2015-05-16 12:31:00 | Spondin 2 regulates hepatic lipid metabolism and alleviates hepatic steatosis, obesity, inflammation, and insulin resistance via its interaction with PPARalpha. | 24445216 |
| Type | IDs |
|---|---|
| Synonymous | 2310045I24Rik, AI504350, M-spondin, Mindin, Mspondin |
| Gene |
UniProtKB-ID:
SPON2_MOUSE
UniprotKB:
Q8BMS2
UniParc:
UPI000002633E
EMBL:
AY457639,
AK028987
Ensembl:
ENSMUSG00000037379
KO:
mmu:100689
|
| Nucleutide sequences |
EMBL-CDS:
BAC26226.1,
AAR20834.1
Ensembl_TRS:
ENSMUST00000046186
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000042701
RefSeq:
XP_006503685.1,
NP_598664.3
|
| Others |
UniRef100:
UniRef100_Q8BMS2
UniRef90:
UniRef90_Q8BMS2
UniRef50:
UniRef50_Q8BMS2
UniGene:
Mm.34694
CCDS:
CCDS19200.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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