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100506658 OCLN

100506658

OCLN

occludin

protein-coding

Homo sapiens

基因描述

Type Description
Definition occludin

研究结论

Date Results Publications
2021-01-02 12:50:00 A homozygote frameshift mutation in OCLN gene result in Pseudo-TORCH syndrome type I: A case report extending the phenotype with central diabetes insipidus and renal dysfunction. 32240828
2020-10-24 13:56:00 Progesterone decreases gut permeability through upregulating occludin expression in primary human gut tissues and Caco-2 cells. 31182728
2020-05-30 10:08:00 miR-424-5p could affect the expression of tight junction proteins, ZO-1 and occludin, via Endophilin-1, and thereby regulate blood brain barrier (BBB) permeability in an BBB model in vitro with Amyloid-beta incubated endothelial cells. 31375213
2020-05-16 11:06:00 Eighteen residues in the c-terminus are essential for occludin trafficking and hepatitis C virus infection. 31328852
2020-05-16 10:04:00 OCLN interacted with mitotic spindle regulators, NuMA and RAN, while full-length OCLN loss impaired spindle pole morphology, astral and mitotic microtubule integrity. 31794381

名称对应

Type IDs
Synonymous BLCPMG, PPP1R115, PTORCH1
Gene
UniProtKB-ID: OCLN_HUMAN, A8K3T2_HUMAN
UniprotKB: Q16625, A8K3T2
UniParc: UPI0001BE98F6, UPI0001DDEB9B, UPI00000341F0, UPI00015DA70F, UPI00004230DE, UPI0000470F95, UPI0001BEA284, UPI0001BEA285
EMBL: GQ402517, U53823, AF400626, BC029886, FJ786083, AC145146, AB451437, GQ225096, AF400630, AF400628, AF400627, AF400624, AK290697, AB451306, AF400623, AC147575, AF400625, GQ225097, FJ786084, BK001650, GQ225098, U49184, AF400629
Ensembl: ENSG00000197822
KO: hsa:100506658
Nucleutide sequences
EMBL-CDS: AAC50451.1, BAG70120.1, ACT83431.1, BAG70251.1, AAB00195.1, ACZ80515.1, ACT53744.1, DAA01837.1, ACT83433.1, AAH29886.1, ACT83432.1, ACT53743.1, AAL47094.1, BAF83386.1
Ensembl_TRS: ENST00000538151, ENST00000396442, ENST00000355237
Protein sequencees
Ensembl_PRO: ENSP00000347379, ENSP00000379719, ENSP00000445940
RefSeq: XP_016864403.1, NP_001192184.1, NP_002529.1, NP_001192183.1, XP_016864402.1
Others
UniRef100: UniRef100_A8K3T2, UniRef100_Q16625
UniRef90: UniRef90_Q16625
UniRef50: UniRef50_Q16625
UniGene: Hs.592605
CCDS: CCDS54864.1, CCDS4006.1

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