| Type | Description |
|---|---|
| Definition | kelch-like 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-21 12:27:00 | Klhl3(M131V/+) KI mice feature typical pseudohypoaldosteronism II with a simultaneous increase of WNK1 and WNK4 through the impaired KLHL3 BTB domain binding to Cul3 | 30148674 |
| 2019-09-07 11:43:00 | deletion of exon 9 from Cul3 generates a protein that is itself ubiquitin-ligase defective but also capable of enhanced autophagocytic KLHL3 degradation | 29897280 |
| 2019-03-09 12:46:00 | decreased abundance of KLHL3 is a specific phenomenon caused by mutant CUL3 (Deltaexon9). | 29869755 |
| 2017-09-16 12:01:00 | However, phosphorylation of and NCC at distal convoluted tubules were almost completely absent even in WNK4(-/-)KLHL3(R528H/R528H) mice. In conclusion, increased WNK1 was unable to compensate for WNK4 deficiency and phosphorylate the NCC, indicating that WNK4 is indispensable for the onset of PHAII. | 28743496 |
| 2017-07-01 10:16:00 | the heterozygous deletion of KLHL3 was not sufficient to cause PHAII, indicating that autosomal dominant type pseudohypoaldosteronism type II (PHAII) is caused by the dominant negative effect of mutant KLHL3. | 28052936 |
| Type | IDs |
|---|---|
| Synonymous | 7530408C15Rik, AI430941, EG627648 |
| Gene | |
| Nucleutide sequences | |
| Protein sequencees |
RefSeq:
XP_006517074.1,
NP_001355796.1,
XP_006517076.1,
XP_006517073.1,
NP_001355797.1,
NP_001349344.2
|
| Others |
UniGene:
Mm.379256,
Mm.491612
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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