| Type | Description |
|---|---|
| Definition | sphingomyelin phosphodiesterase, acid-like 3B |
| Date | Results | Publications |
|---|---|---|
| 2019-07-13 11:14:00 | Study reports that Smpdl3b excess, as observed in podocytes in diabetic kidney disease, impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insulin receptor isoforms binding to caveolin-1 in the plasma membrane. | 31217420 |
| 2017-09-02 12:35:00 | These results demonstrate that radiation injury induces early cytoskeletal remodeling, down-regulation of SMPDL3b, and elevation of cellular ceramide levels. Overexpression of SMPDL3b and pretreatment with rituximab confer a radioprotective effect in cultured podocytes. | 27836988 |
| 2017-05-27 11:07:00 | Although a potential substrate for SMPDL3B is sphingomyelin, we identify other possible substrates such as CDP-choline, ATP, and ADP. | 27687724 |
| 2016-03-26 10:17:00 | our results identify the membrane-modulating enzyme SMPDL3B as a negative regulator of TLR signaling that functions at the interface of membrane biology and innate immunity. | 26095358 |
| 2015-03-21 11:38:00 | SMPDL3b may be an important modulator of podocyte function by shifting suPAR-mediated podocyte injury from a migratory phenotype to an apoptotic phenotype and that it represents a novel therapeutic glomerular disease target | 24925721 |
| Type | IDs |
|---|---|
| Synonymous | 1110054A24Rik, AU045240, Asml3b |
| Gene |
UniProtKB-ID:
ASM3B_MOUSE,
Q3TLX9_MOUSE
UniprotKB:
P58242,
Q3TLX9
UniParc:
UPI000002301F
EMBL:
AK166253,
BC009087,
AK154599
Ensembl:
ENSMUSG00000028885
KO:
mmu:100340
|
| Nucleutide sequences |
EMBL-CDS:
AAH09087.1,
BAE32702.1,
BAE38663.1
Ensembl_TRS:
ENSMUST00000030709
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000030709
RefSeq:
XP_036019446.1,
NP_598649.1
|
| Others |
UniRef100:
UniRef100_P58242
UniRef90:
UniRef90_P58242
UniRef50:
UniRef50_P58242
UniGene:
Mm.287187
CCDS:
CCDS18733.1
|
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31217420 |
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease. Nat Commun A Mitrofanova , S K Mallela , G M Ducasa , T H Yoo , E Rosenfeld-Gur , I D Zelnik , J Molina , J Varona Santos , M Ge , A Sloan , J J Kim , C Pedigo , J Bryn , I Volosenco , C Faul , Y H Zeidan , C Garcia Hernandez , A J Mendez , I Leibiger , G W Burke , A H Futerman , L Barisoni , Y Ishimoto , R Inagi , S Merscher , A Fornoni |
2019-06-19 | - |
| 27836988 |
Sphingomyelinase-like phosphodiesterase 3b mediates radiation-induced damage of renal podocytes. FASEB J. Anis Ahmad , Alla Mitrofanova , Jacek Bielawski , Yidong Yang , Brian Marples , Alessia Fornoni , Youssef H Zeidan |
2017-02-01 | - |
| 27687724 |
J Biol Chem Alexei Gorelik , Leonhard X Heinz , Katalin Illes , Giulio Superti-Furga , Bhushan Nagar |
2016-11-11 | - |
| 26095358 |
The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Rep Leonhard X Heinz , Christoph L Baumann , Marielle S Köberlin , Berend Snijder , Riem Gawish , Guanghou Shui , Omar Sharif , Irene M Aspalter , André C Müller , Richard K Kandasamy , Florian P Breitwieser , Andreas Pichlmair , Manuela Bruckner , Manuele Rebsamen , Stephan Blüml , Thomas Karonitsch , Astrid Fauster , Jacques Colinge , Keiryn L Bennett , Sylvia Knapp , Markus R Wenk , Giulio Superti-Furga |
2015-06-30 | - |
| 25758223 |
A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development Katharina Walentin , Christian Hinze , Max Werth , Nadine Haase , Saaket Varma , Robert Morell , Annekatrin Aue , Elisabeth Pötschke , David Warburton , Andong Qiu , Jonathan Barasch , Bettina Purfürst , Christoph Dieterich , Elena Popova , Michael Bader , Ralf Dechend , Anne Cathrine Staff , Zeliha Yesim Yurtdas , Ergin Kilic , Kai M Schmidt-Ott |
2015-03-15 | - |
| 24925721 |
J. Am. Soc. Nephrol. Tae-Hyun Yoo , Christopher E Pedigo , Johanna Guzman , Mayrin Correa-Medina , Changli Wei , Rodrigo Villarreal , Alla Mitrofanova , Farah Leclercq , Christian Faul , Jing Li , Matthias Kretzler , Robert G Nelson , Markku Lehto , Carol Forsblom , Per-Henrik Groop , Jochen Reiser , George William Burke , Alessia Fornoni , Sandra Merscher |
2015-01-01 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21677750 |
A conditional knockout resource for the genome-wide study of mouse gene function. Nature William C Skarnes , Barry Rosen , Anthony P West , Manousos Koutsourakis , Wendy Bushell , Vivek Iyer , Alejandro O Mujica , Mark Thomas , Jennifer Harrow , Tony Cox , David Jackson , Jessica Severin , Patrick Biggs , Jun Fu , Michael Nefedov , Pieter J de Jong , A Francis Stewart , Allan Bradley |
2011-06-15 | - |
| 19884258 |
Genes Dev. Steven C Munger , David L Aylor , Haider Ali Syed , Paul M Magwene , David W Threadgill , Blanche Capel |
2009-11-01 |
Smpdl3b,
Slco3a1,
Nr0b1,
Axin2,
B2m,
Ctnnb1,
Cbln1,
Col9a3,
Cst9,
Dclk1,
Dhh,
Dtna,
Ereg,
Fgf9,
Fst,
Gata4,
Pcsk6,
Pld1,
Ptgds,
Rspo1,
Ptpre,
Ren1,
Sox8,
Sox9,
Sphk1,
Serpine2,
Tbp,
Socs2,
Sry,
Acap1,
Trim47,
Pglyrp1,
Tpd52l1,
Tfrc,
Wnt4,
Wt1,
Zfpm2,
Rtn4rl1,
Dock4,
Defb7,
Prokr2,
Defb19,
Nr5a1,
Asns,
Col27a1,
Smoc2,
Gng13,
Actr6,
Dapk1,
Pdgfd,
Taf7l,
Mmd2,
Rpgrip1
|
| 18799693 |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. Gwenn M Hansen , Diane C Markesich , Michael B Burnett , Qichao Zhu , Karen M Dionne , Lizabeth J Richter , Richard H Finnell , Arthur T Sands , Brian P Zambrowicz , Alejandro Abuin |
2008-10-01 |
Gm11335,
Gm17762,
A930017K11Rik,
BC028777,
Gm13999,
Gm11696,
Gm12359,
Gm10589,
D030047H15Rik,
Gm10856,
Gm10685,
Gm10062,
Gm10433,
Gm10648,
Gm10840,
Gm15441,
Gm10684,
Gm9900,
Gm10822,
Gm10687,
Gm11744,
Gm10747,
Arih2os,
B230344G16Rik,
Fmr1os,
Tmem51os1,
Gm14488,
Gm13033,
Gm10789,
Gm10615,
Gm1976,
Gm9967,
Gm9917,
Gm1974,
Gm11496,
Gm13580,
Gm2085,
Gm2183,
Gm2245,
Tbx3os1,
Gm12980,
Gm2329,
Lncenc1,
Gm2381,
Snhg12,
Gm2479,
Gm12942,
Gm2529,
Gm2533,
Rpl30-ps7,
Rsf1os2,
Gm2695,
2810416G20Rik,
Rpl30-ps6,
Gm2773,
Gm2788,
Dynlt1f,
Gm9793,
Gm2885,
Gm2920,
Gm15506,
Gm11627,
Gm10518,
Gm13496,
Gm3134,
Gm12827,
Gm3143,
Gm10144,
Ahnak2,
Gm3196,
Gm13242,
Gm3325,
Gm13247,
Gm10863,
Gm13157,
4930522L14Rik,
Gm3552,
Gm15226,
Gm3604,
Gm3643,
BC005561,
Gm3716,
2810410L24Rik,
Gm10282,
Gm3839,
Nhsl2,
4732419C18Rik,
Gm3906,
Gm3973,
Gm4013,
Apol7d,
Gm12057,
Gm10489,
Rex2,
1110002L01Rik,
Gm4189,
Gm4204,
4632428C04Rik,
9130023H24Rik
|
| 排名 | 科研单位 | 文献 |
|---|
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|
目前还没有研究热点人员