| Type | Description |
|---|---|
| Definition | sphingomyelin phosphodiesterase, acid-like 3B |
| Date | Results | Publications |
|---|---|---|
| 2019-07-13 11:14:00 | Study reports that Smpdl3b excess, as observed in podocytes in diabetic kidney disease, impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insulin receptor isoforms binding to caveolin-1 in the plasma membrane. | 31217420 |
| 2017-09-02 12:35:00 | These results demonstrate that radiation injury induces early cytoskeletal remodeling, down-regulation of SMPDL3b, and elevation of cellular ceramide levels. Overexpression of SMPDL3b and pretreatment with rituximab confer a radioprotective effect in cultured podocytes. | 27836988 |
| 2017-05-27 11:07:00 | Although a potential substrate for SMPDL3B is sphingomyelin, we identify other possible substrates such as CDP-choline, ATP, and ADP. | 27687724 |
| 2016-03-26 10:17:00 | our results identify the membrane-modulating enzyme SMPDL3B as a negative regulator of TLR signaling that functions at the interface of membrane biology and innate immunity. | 26095358 |
| 2015-03-21 11:38:00 | SMPDL3b may be an important modulator of podocyte function by shifting suPAR-mediated podocyte injury from a migratory phenotype to an apoptotic phenotype and that it represents a novel therapeutic glomerular disease target | 24925721 |
| Type | IDs |
|---|---|
| Synonymous | 1110054A24Rik, AU045240, Asml3b |
| Gene |
UniProtKB-ID:
ASM3B_MOUSE,
Q3TLX9_MOUSE
UniprotKB:
P58242,
Q3TLX9
UniParc:
UPI000002301F
EMBL:
AK166253,
BC009087,
AK154599
Ensembl:
ENSMUSG00000028885
KO:
mmu:100340
|
| Nucleutide sequences |
EMBL-CDS:
AAH09087.1,
BAE32702.1,
BAE38663.1
Ensembl_TRS:
ENSMUST00000030709
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000030709
RefSeq:
XP_036019446.1,
NP_598649.1
|
| Others |
UniRef100:
UniRef100_P58242
UniRef90:
UniRef90_P58242
UniRef50:
UniRef50_P58242
UniGene:
Mm.287187
CCDS:
CCDS18733.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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