| Type | Description |
|---|---|
| Definition | microRNA 664a |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:34:00 | The long noncoding RNA OTUD6B-AS1 enhances cell proliferation and the invasion of hepatocellular carcinoma cells through modulating GSKIP/Wnt/beta-catenin signalling via the sequestration of miR-664b-3p. | 32682012 |
| 2020-07-11 10:20:00 | identified miR-664a-5p-HMGA2 pathway expands the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (BMSCs), may provide deeper insights into the regulation of this differentiation, and can point to new effective methods for treating osteoporosis | 31630797 |
| 2020-04-18 11:28:00 | The present study validated significant upregulation of hsa-miR-664a-3p in COPD patients, and its target gene FHL1 was downregulated and positively correlated with FEV1/FVC%; both hsa-miR-664a-3p and FHL1 could be regulated by cigarette smoke extract. Results of bioinformatic analyses and expanded validation suggest that the axis from hsa-miR-664a-3p to FHL1 might play a key role in cigarette smoke-induced COPD, and the e | 31632001 |
| 2020-04-04 12:37:00 | miR-664 was remarkably high in cutaneous squamous cell carcinomas (cSCC) patient specimens and cSCC cell lines. Study identified IRF2 as a direct downstream target of miR-664. Knockdown of IRF2 reverses pro-tumorigenesis phenotype of miR-664; whereas IRF2 over-expression inhibits miR-664 tumorigenesis in cSCC. Together, it revealed miR-664 functions as an oncogene in cSCC via suppression of IRF2. | 31138473 |
| 2019-08-17 12:55:00 | Study demonstrated that miR664 is an important tumor suppressor in pancreatic ductal adenocarcinoma (PDAC) progression. The upregulation of miR664 suppresses the malignant behaviors of PDAC cells in vitro and in vivo by directly targeting PAX6 and inactivating PI3K/Akt pathway, while miR664 downregulation promotes these behaviors. | 30896829 |
| Type | IDs |
|---|---|
| Synonymous | MIR664, MIRN664, hsa-mir-664, hsa-mir-664a, mir-664a |