GRB2 - growth factor receptor bound protein 2-BMKCloudï½ç¾è¿å®¢äº

100192436 GRB2

基因描述

Type	Description
Definition	growth factor receptor bound protein 2

研究结论

Date	Results	Publications
2010-01-21 00:00:00	in VSMCs exposed to hyperglycemia, IGF-I stimulation of Shc facilitates the transfer of Grb2 to p85 resulting in enhanced PI3K activation and AKT phosphorylation leading to enhanced cell proliferation and migration	18420583

名称对应

Type	IDs
Gene	UniProtKB-ID: B6E241_PIG, A0A4X1UZ70_PIG UniprotKB: B6E241, A0A4X1UZ70 UniParc: UPI000004EF93 EMBL: FJ196595, AEMK02000080, DQIR01270002 Ensembl: ENSSSCG00000017206, ENSSSCG00070021340 KO: ssc:100192436
Nucleutide sequences	EMBL-CDS: HDC25480.1, ACI29749.1 Ensembl_TRS: ENSSSCT00000018731, ENSSSCT00070042421
Protein sequencees	Ensembl_PRO: ENSSSCP00000018229, ENSSSCP00070035666 RefSeq: NP_001131100.1
Others	UniRef100: UniRef100_P62993 UniRef90: UniRef90_P62993 UniRef50: UniRef50_P62993 UniGene: Ssc.41215

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{{proteinIndex+1}}	mRNA	Protein	UniprotKB	Description
Refseq	{{protein.nucleotideVersion}} Ensembl: {{protein.nucleotideEnsembl}}	{{protein.proteinVersion}} Ensembl: {{protein.proteinEnsembl}}	{{uniprot}}	Definition: {{{protein.definition}}} Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}}
Location	( {{protein.positionStart}}..{{protein.positionEnd}} )
Conserved domain	Region: {{conservedDomain.region == '' \|\| conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' \|\| conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' \|\| conservedDomain.family == null ? "-": conservedDomain.family}} CDD:	{{conservedDomain.comments == '' \|\| conservedDomain.comments == null ? "-" : conservedDomain.comments }}	Region: {{conservedDomain.region == '' \|\| conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' \|\| conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' \|\| conservedDomain.family == null ? "-": conservedDomain.family}} CDD:	{{conservedDomain.comments == '' \|\| conservedDomain.comments == null ? "-" : conservedDomain.comments }}

mRNA

Protein

UniprotKB

Description

Refseq

Ensembl: {{protein.nucleotideEnsembl}}

Ensembl: {{protein.proteinEnsembl}}

Definition: {{{protein.definition}}}

Transcript Veriant:{{protein.transcriptVeriant}}

Status: {{protein.status}}

Location

( {{protein.positionStart}}..{{protein.positionEnd}} )

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Pubmed编号	文献信息	发表日期	相关基因
18420583	Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells. J Biol Chem Yashwanth Radhakrishnan , Laura A Maile , Yan Ling , Lee M Graves , David R Clemmons	2008-06-13	-
15679890	Comparative analysis of protein coding sequences from human, mouse and the domesticated pig. BMC Biol. Frank GrÃ¸nlund JÃ¸rgensen , Asger Hobolth , Henrik HornshÃ¸j , Christian Bendixen , Merete Fredholm , Mikkel Heide Schierup	2005-01-01	NREP, P4HA1, LOC100037988, RPL14, RPL27, RPS26, SNRPE, EIF4E2, ACOX1, COPS5, COPS2, COPS4, CD302, CNPY3, GATM, SUMO1, LMO4, HNRNPAB, SMNDC1, CAPZB, PRELID3B, AIMP1, SPCS1, DEGS1, H2AFZ, RPL7L1, PON2, HEXA, UCHL5, RAB34, RAB5A, RNF5, PHGDH, ITLN2, TMCO1, TAF11, RAB2A, VIMP, SDCBP, ARV1, PMP2, MRPL2, TPD52, AIG1, C1H15orf61, LOC100152047, ENPP6, COMMD4, POLR3GL, PLEKHO1, SSB, CMSS1, AGA, CUTA, PEX7, COX6A1, PMVK, MTERF3, CD53, FRZB, PEA15, ERH, TMEM242, CTHRC1, MED6, FAM162B, FAM204A, PDZK1, DPCD, HAUS1, COQ10B, BNIP3L, SSR1, MRPS28, SDC2, DHRS7, TOMM20, DNAJB11, BZW1, CXHXorf56, GNPNAT1, BOLA1, PDCD7, PFDN6, LOC100153062, DTWD1, UBE2C, STK16, DNPEP, ARPC2, SIT1, STX7, WDR61, PPP6C, TIPIN, MYF5, MRPL13, CHCHD1, EAPP
14681463	PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Nucleic Acids Res. Hirohide Uenishi , Tomoko Eguchi , Kohei Suzuki , Tetsuya Sawazaki , Daisuke Toki , Hiroki Shinkai , Naohiko Okumura , Noriyuki Hamasima , Takashi Awata	2004-01-01	PIK3R6, DESI2, ENPP1, SPARCL1, NREP, SLA-3, IRF7, DYNC1H1, SLA-1, P4HA1, DNMT3A, SEPHS2, SGMS1, CPE, BIN1, TNFRSF1B, SLA-DQB1, CD14, APOBEC3F, PDE4B, KCND3, KCNIP2, UIMC1, LOC100037950, C9, C6, C8A, C8B, C8G, LOC100037957, CAPZA2, CTSB, SEPP1, LOC100037968, SLC7A7, C2H19orf70, ATP5J2, PET100, TOMM7, NDUFC1, SLIRP, LOC100037988, COX6C, COX7C, NDUFV2, PSMB7, RPL10A, RPL14, RPL27, RPS21, RPS26, TMSB10, TPM1, ATPIF1, KLF7, RCHY1, PCD1B, CD1E, SEP15, CCL11, CD72, PVRL2, COX6B, RPS6, CLEC7A, RPL4, EIF4E, LGALS3, SNRPE, ZFAND5, ADSS, SDHD, C5AR1, BTG3, GNA14, NAGS, TNMD, ABCG8, YWHAQ, PGRMC2, CYB561, CNN3, GNAS, RBM39, BRCA1, EDN3, KRT2, HPS4, BLOC1S5, BLOC1S6, RABGGTA, MLPH, ATP7B, CRYZL1, PNPLA3, SRGN, SPTAN1, BIRC6, HPS5

Pubmed编号

文献信息

发表日期

相关基因

18420583

Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells.

J Biol Chem Yashwanth Radhakrishnan , Laura A Maile , Yan Ling , Lee M Graves , David R Clemmons

2008-06-13

15679890

Comparative analysis of protein coding sequences from human, mouse and the domesticated pig.

BMC Biol. Frank GrÃ¸nlund JÃ¸rgensen , Asger Hobolth , Henrik HornshÃ¸j , Christian Bendixen , Merete Fredholm , Mikkel Heide Schierup

2005-01-01

NREP, P4HA1, LOC100037988, RPL14, RPL27, RPS26, SNRPE, EIF4E2, ACOX1, COPS5, COPS2, COPS4, CD302, CNPY3, GATM, SUMO1, LMO4, HNRNPAB, SMNDC1, CAPZB, PRELID3B, AIMP1, SPCS1, DEGS1, H2AFZ, RPL7L1, PON2, HEXA, UCHL5, RAB34, RAB5A, RNF5, PHGDH, ITLN2, TMCO1, TAF11, RAB2A, VIMP, SDCBP, ARV1, PMP2, MRPL2, TPD52, AIG1, C1H15orf61, LOC100152047, ENPP6, COMMD4, POLR3GL, PLEKHO1, SSB, CMSS1, AGA, CUTA, PEX7, COX6A1, PMVK, MTERF3, CD53, FRZB, PEA15, ERH, TMEM242, CTHRC1, MED6, FAM162B, FAM204A, PDZK1, DPCD, HAUS1, COQ10B, BNIP3L, SSR1, MRPS28, SDC2, DHRS7, TOMM20, DNAJB11, BZW1, CXHXorf56, GNPNAT1, BOLA1, PDCD7, PFDN6, LOC100153062, DTWD1, UBE2C, STK16, DNPEP, ARPC2, SIT1, STX7, WDR61, PPP6C, TIPIN, MYF5, MRPL13, CHCHD1, EAPP

14681463

PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries.

Nucleic Acids Res. Hirohide Uenishi , Tomoko Eguchi , Kohei Suzuki , Tetsuya Sawazaki , Daisuke Toki , Hiroki Shinkai , Naohiko Okumura , Noriyuki Hamasima , Takashi Awata

2004-01-01

PIK3R6, DESI2, ENPP1, SPARCL1, NREP, SLA-3, IRF7, DYNC1H1, SLA-1, P4HA1, DNMT3A, SEPHS2, SGMS1, CPE, BIN1, TNFRSF1B, SLA-DQB1, CD14, APOBEC3F, PDE4B, KCND3, KCNIP2, UIMC1, LOC100037950, C9, C6, C8A, C8B, C8G, LOC100037957, CAPZA2, CTSB, SEPP1, LOC100037968, SLC7A7, C2H19orf70, ATP5J2, PET100, TOMM7, NDUFC1, SLIRP, LOC100037988, COX6C, COX7C, NDUFV2, PSMB7, RPL10A, RPL14, RPL27, RPS21, RPS26, TMSB10, TPM1, ATPIF1, KLF7, RCHY1, PCD1B, CD1E, SEP15, CCL11, CD72, PVRL2, COX6B, RPS6, CLEC7A, RPL4, EIF4E, LGALS3, SNRPE, ZFAND5, ADSS, SDHD, C5AR1, BTG3, GNA14, NAGS, TNMD, ABCG8, YWHAQ, PGRMC2, CYB561, CNN3, GNAS, RBM39, BRCA1, EDN3, KRT2, HPS4, BLOC1S5, BLOC1S6, RABGGTA, MLPH, ATP7B, CRYZL1, PNPLA3, SRGN, SPTAN1, BIRC6, HPS5

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