MTOR - mechanistic target of rapamycin kinase-BMKCloudï½ç¾è¿å®¢äº

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100127359 MTOR

基因描述

Type	Description
Definition	mechanistic target of rapamycin kinase

研究结论

Date	Results	Publications
2020-05-09 12:06:00	Valine supplementation increases protein synthesis and cell proliferation in porcine mammary epithelial cells. These changes are associated with elevated phosphorylation levels of mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase (S6) and eukaryotic initiation factor 4E-binding protein-1 (4EBP1) in valine-supplemented cells, which can be effectively blocked by the antagonists of mTOR.	31720834
2018-12-01 11:24:00	The addition of methionine source mixes in porcine mammary tissue slices improves the abundance of phosphorylated-mechanistic target of rapamycin (P-mTOR) and mTOR. However, the abundance of P-mTOR and mTOR proteins is not affected by the addition of single methionine sources. mTORC1 protein synthesis in porcine mammary glands is regulated by the local available methionine depending on methionine sources.	28983783
2017-09-02 12:09:00	The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.	28257428
2017-07-01 13:01:00	These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.	27225947
2017-05-13 16:58:00	In summary, mTORC1 signaling is a key mechanism of PARylation-autophagy and its inhibition improved developmental ability and embryo quality by promoting selective autophagic degradation of ubiquitinated aggregates in porcine blastocysts.	27040764

名称对应

Type	IDs
Synonymous	FRAP1
Gene	UniProtKB-ID: A0A4X1W882_PIG, F1RHR8_PIG UniprotKB: A0A4X1W882, F1RHR8 UniParc: UPI00022CDBFE EMBL: DQIR01259080, AEMK02000044 Ensembl: ENSSSCG00000003413, ENSSSCG00070029477 KO: ssc:100127359
Nucleutide sequences	EMBL-CDS: HDC14558.1 Ensembl_TRS: ENSSSCT00070059230, ENSSSCT00070059232, ENSSSCT00000003786
Protein sequencees	Ensembl_PRO: ENSSSCP00070050428, ENSSSCP00070050430, ENSSSCP00000003699 RefSeq: XP_003127632.3
Others	UniRef100: UniRef100_A0A4X1W882 UniRef90: UniRef90_P42345 UniRef50: UniRef50_P42345 UniGene: Ssc.101527

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
31720834	Valine supplementation during late pregnancy in gilts increases colostral protein synthesis through stimulating mTOR signaling pathway in mammary cells. Amino Acids Long Che , Mengmeng Xu , Kaiguo Gao , Li Wang , Xuefen Yang , Xiaolu Wen , Hao Xiao , Zongyong Jiang , De Wu	2019-11-01	-
28983783	mTORC1 signaling-associated protein synthesis in porcine mammary glands was regulated by the local available methionine depending on methionine sources. Amino Acids Yalin Zhang , Peng Wang , Sen Lin , Yves Mercier , Huajun Yin , Yumo Song , Xiaoling Zhang , Lianqiang Che , Yan Lin , Shengyu Xu , Bin Feng , De Wu , Zhengfeng Fang	2018-01-01	-
28257428	Dietary protein-induced hepatic IGF-1 secretion mediated by PPARÎ³ activation. PLoS One Xiaojuan Wan , Songbo Wang , Jingren Xu , Lu Zhuang , Kongping Xing , Mengyuan Zhang , Xiaotong Zhu , Lina Wang , Ping Gao , Qianyun Xi , Jiajie Sun , Yongliang Zhang , Tiejun Li , Gang Shu , Qingyan Jiang	2017-01-01	-
27225947	Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS. Am J Physiol Regul Integr Comp Physiol Yulan Liu , Xiuying Wang , Huanting Wu , Shaokui Chen , Huiling Zhu , Jing Zhang , Yongqing Hou , Chien-An Andy Hu , Guolong Zhang	2016-08-01	-
27102282	Uroguanylin modulates (Na++K+)ATPase in a proximal tubule cell line: Interactions among the cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways. Biochim. Biophys. Acta Francisco J Arnaud-Batista , Diogo B Peruchetti , Thiago P Abreu , Nilberto R F do Nascimento , Gerhard Malnic , Manasses C Fonteles , Celso Caruso-Neves	2016-07-01	-
27040764	The regulation of autophagy in porcine blastocysts: Regulation of PARylation-mediated autophagy via mammalian target of rapamycin complex 1 (mTORC1) signaling. Biochem Biophys Res Commun Hye Ran Lee , Duk Hyoun Kim , Min Gyeong Kim , Jun Sung Lee , Jeong Ho Hwang , Hoon Taek Lee	2016-05-13	-
26967195	Global Liver Proteome Analysis Using iTRAQ Reveals AMPK-mTOR-Autophagy Signaling Is Altered by Intrauterine Growth Restriction in Newborn Piglets. J. Proteome Res. Baisheng Long , Cong Yin , Qiwen Fan , Guokai Yan , Zhichang Wang , Xiuzhi Li , Changqing Chen , Xingya Yang , Lu Liu , Zilong Zheng , Min Shi , Xianghua Yan	2016-04-01	-
27459644	Mammalian Target of Rapamycin Signaling Pathway Changes with Intestinal Epithelial Cells Renewal Along Crypt-Villus Axis. Cell. Physiol. Biochem. Huansheng Yang , Xia Xiong , Xiaocheng Wang , Yulong Yin	2016-01-01	-
25739982	mTOR is involved in 17Î²-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1. Mol. Reprod. Dev. Wei-Rong Yang , Yong Wang , Yi Wang , Jiao-Jiao Zhang , Jia-Hua Zhang , Cheng Lu , Xian-Zhong Wang	2015-04-01	MTOR
25280462	L-Glutamine enhances enterocyte growth via activation of the mTOR signaling pathway independently of AMPK. Amino Acids Dan Yi , Yongqing Hou , Lei Wang , Wanjin Ouyang , Minhui Long , Di Zhao , Binying Ding , Yulan Liu , Guoyao Wu	2015-01-01	MTOR, PRKAA1

研究热度

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