| Type | Description |
|---|---|
| Definition | interferon induced with helicase C domain 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-07-29 11:54:00 | study identifies the porcine 2'-5'-oligoadenylate synthetase-like protein (pOASL) as an interferon (IFN)-stimulated gene (ISG) against classical swine fever virus (CSFV); show that pOASL, as an MDA5-interacting protein, is a coactivator of MDA5-mediated IFN induction to exert anti-CSFV actions | 28331099 |
| 2014-06-28 12:13:00 | These data indicate that classical swine fever virus can be recognized by both RIG-I and MDA5 to initiate the RIG-I signaling pathway to trigger innate defenses against infection. | 24034559 |
| 2013-02-23 11:19:00 | crystal structure of the MDA5 ATP-hydrolysis domain in complex with parainfluenzavirus 5 V protein; the V protein unfolded the ATP-hydrolysis domain of MDA5 and recognized a structural motif of MDA5 normally buried in the helicase fold leading to disruption of MDA5 ATP-hydrolysis site and prevention of RNA-bound MDA5 filament formation | 23328395 |
| 2010-01-21 00:00:00 | IFIH1 had only one nonsynonymous SNP in the helicase domain. | 19099299 |
| Type | IDs |
|---|---|
| Synonymous | MDA5 |
| Gene |
UniProtKB-ID:
A7LCX1_PIG,
A0A286ZT21_PIG
UniprotKB:
A7LCX1,
A0A286ZT21
UniParc:
UPI00015932C1,
UPI0003AF0392
EMBL:
EU006039,
AEMK02000100,
DQIR01124764
Ensembl:
ENSSSCG00000015897
KO:
ssc:100101927
|
| Nucleutide sequences |
EMBL-CDS:
ABS29718.1,
HDA80240.1
Ensembl_TRS:
ENSSSCT00000032969
|
| Protein sequencees |
Ensembl_PRO:
ENSSSCP00000034792
RefSeq:
NP_001093664.1,
XP_005671938.1
|
| Others |
UniRef100:
UniRef100_A0A286ZT21,
UniRef100_A0A2S1PVX7
UniRef90:
UniRef90_A0A287AKR1
UniRef50:
UniRef50_Q9BYX4
UniGene:
Ssc.19139
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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