CFTR - cystic fibrosis transmembrane conductance regulator-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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100049619 CFTR

基因描述

Type	Description
Definition	cystic fibrosis transmembrane conductance regulator

研究结论

Date	Results	Publications
2019-07-13 11:11:00	observe an extracellular vestibule that may provide anion access to the pore due to the conformation of transmembrane helices 7 and 8 that differs from the previous orthologue CFTR structures	30281975
2018-06-23 10:48:00	Study demonstrated a neuronal role for CFTR in regulating cytosolic Cl- in response to NO, thus regulating the strength or even the sign of postsynaptic GABAergic and glycinergic responses. The involvement of CFTR in this fundamental aspect of neuronal physiology contributes to filling the gap in our understanding of neuronal Cl- regulation.	28835528
2012-03-17 12:24:00	These data support the conclusion that avian renal proximal tubules utilize an apical CFTR Cl(-) channel to mediate cAMP-activated Cl(-) secretion.	21964154

名称对应

Type	IDs
Gene	UniProtKB-ID: A0A1D5PBN0_CHICK, A0M8U4_CHICK UniprotKB: A0A1D5PBN0, A0M8U4 UniParc: UPI000739E0B1, UPI0000E747A5 EMBL: AADN05000096, AC159212, DP000235 Ensembl: ENSGALG00000032986 KO: gga:100049619
Nucleutide sequences	EMBL-CDS: ABK34432.1 Ensembl_TRS: ENSGALT00000047691
Protein sequencees	Ensembl_PRO: ENSGALP00000050160 RefSeq: NP_001099136.1, XP_015131458.1
Others	UniRef100: UniRef100_A0A1D5PBN0, UniRef100_A0M8U4 UniRef90: UniRef90_A0M8U4, UniRef90_A0A1D5PBN0 UniRef50: UniRef50_P13569 UniGene: Gga.27462

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
30281975	Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel. Biochemistry Jonathan F Fay , Luba A Aleksandrov , Timothy J Jensen , Liying L Cui , Joseph N Kousouros , Lihua He , Andrei A Aleksandrov , Drew S Gingerich , John R Riordan , James Z Chen	2018-10-30	-
28835528	A role for the cystic fibrosis transmembrane conductance regulator in the nitric oxide-dependent release of Cl^- from acidic organelles in amacrine cells. J. Neurophysiol. Vijai Krishnan , J Wesley Maddox , Tyler Rodriguez , Evanna Gleason	2017-11-01	-
21964154	CFTR mediated chloride secretion in the avian renal proximal tubule. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Gary Laverty , Ashley Anttila , Jenava Carty , Varudhini Reddy , Jamie Yum , Sighvatur S Arnason	2012-01-01	CFTR
12917688	Comparative analyses of multi-species sequences from targeted genomic regions. Nature J W Thomas , J W Touchman , R W Blakesley , G G Bouffard , S M Beckstrom-Sternberg , E H Margulies , M Blanchette , A C Siepel , P J Thomas , J C McDowell , B Maskeri , N F Hansen , M S Schwartz , R J Weber , W J Kent , D Karolchik , T C Bruen , R Bevan , D J Cutler , S Schwartz , L Elnitski , J R Idol , A B Prasad , S-Q Lee-Lin , V V B Maduro , T J Summers , M E Portnoy , N L Dietrich , N Akhter , K Ayele , B Benjamin , K Cariaga , C P Brinkley , S Y Brooks , S Granite , X Guan , J Gupta , P Haghighi , S-L Ho , M C Huang , E Karlins , P L Laric , R Legaspi , M J Lim , Q L Maduro , C A Masiello , S D Mastrian , J C McCloskey , R Pearson , S Stantripop , E E Tiongson , J T Tran , C Tsurgeon , J L Vogt , M A Walker , K D Wetherby , L S Wiggins , A C Young , L-H Zhang , K Osoegawa , B Zhu , B Zhao , C L Shu , P J De Jong , C E Lawrence , A F Smit , A Chakravarti , D Haussler , P Green , W Miller , E D Green	2003-08-14	Capza2, Cav1, Cav2, Cftr, Met, Wnt2, St7, Asz1, Asz1, Cttnbp2, ST7, Tes, LOC100137129, dusp6, cep41, tes, cav2, cav1, capza2, cortbp2, atp2b1, cpa1, met, wnt2, st7, met, wnt2, cav1, cav2, cftr, asz1, st7, CFTR, CAV1, TES, MET, CTTNBP2, ASZ1, WNT2, ST7, CAPZA2, ASZ1, CAV1, CAV2, TES, MET, CTTNBP2, ST7, CAPZA2, WNT2, CFTR, ASZ1, TES, CAV1, MET, ST7, WNT2, CFTR, CAV2, CAPZA2, TES, CTTNBP2, MET, CAV1, TES, CAV2, ST7, CFTR, CAPZA2, TES, CAV2, MET, CAPZA2, ST7, WNT2, CTTNBP2, CAPZA2, CAV2, TES, CTTNBP2, ST7, WNT2, CFTR, CAV1, MET, MET, CAV1, ASZ1, CAPZA2

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