| Type | Description |
|---|---|
| Definition | T cell immunoreceptor with Ig and ITIM domains |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 12:41:00 | These data therefore identify a function of TIGIT in limiting immune pathology that is independent of viral clearance. | 32152316 |
| 2020-05-30 12:22:00 | A pivotal role for CD226 in attenuating Treg function in EAE that was associated with downregulating the expression levels of CTLA-4 and TIGIT. | 31919790 |
| 2019-10-19 11:47:00 | Results indicate that TIGIT enhanced on tolerant T cells may function as a ligand of its paired receptor CD155 to transduce signaling into its expressing naive T cells to accelerate new TIGIT expressions as well as IL-2 suppression via B lymphocyte-induced maturation protein 1 enhancement. | 31022697 |
| 2019-04-20 11:36:00 | TIGIT was associated with NK cell exhaustion in tumor-bearing mice and patients with colon cancer. | 29915296 |
| 2019-02-16 11:23:00 | high expression of TIGIT found on hepatic CD8+ T cells of HBsAg transgenic mice, which are immunologically tolerant to hepatitis B virus; blockade or deficiency of TIGIT in HBsAg-tg mice triggered hepatocellular carcinoma development in a CD8+ T cell-dependent manner | 30644386 |
| Type | IDs |
|---|---|
| Synonymous | Vstm3 |
| Gene |
UniProtKB-ID:
A0A0B4J1G6_MOUSE
UniprotKB:
A0A0B4J1G6
UniParc:
UPI000058A9B2
EMBL:
AC154408,
AC120871
Ensembl:
ENSMUSG00000071552
KO:
mmu:100043314
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000096065
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000093770
RefSeq:
XP_017172323.1,
NP_001139797.1
|
| Others |
UniRef100:
UniRef100_A0A0B4J1G6
UniRef90:
UniRef90_P86176
UniRef50:
UniRef50_P86176
UniGene:
Mm.390896
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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