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100038570 Prcd

100038570

Prcd

photoreceptor disc component

protein-coding

Mus musculus

基因描述

Type Description
Definition photoreceptor disc component

研究结论

Date Results Publications
2021-03-06 13:29:00 TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments. 33213002
2020-12-19 13:44:00 Loss of PRCD alters number and packaging density of rhodopsin in rod photoreceptor disc membranes. 33087780
2020-06-27 12:29:00 This study has important implications for understanding the function of PRCD in the retina, as well as for future development of treatment modalities for PRCD deficiency in humans. 31628458
2020-04-11 12:29:00 Study in Prcd knockout mice found that Prcd functions at the site of photoreceptor disc morphogenesis where it is required to keep newly forming discs flat as they protrude from the plasma membrane. Without Prcd, the newly forming discs bulge and release extracellular vesicles, which accumulate in the extracellular space and ultimately lead to retinal pathology. 31189593
2017-09-30 13:36:00 Disrupting PRCD palmitoylation eliminating the modified cysteine dramatically affects the stability of PRCD. 27613864

名称对应

Type IDs
Synonymous Gm11744
Gene
UniProtKB-ID: PRCD_MOUSE
UniprotKB: Q00LT2
UniParc: UPI00001E6ABA
EMBL: DQ390337
Ensembl: ENSMUSG00000075410
KO: mmu:100038570
Nucleutide sequences
EMBL-CDS: ABD17428.1
Ensembl_TRS: ENSMUST00000148484, ENSMUST00000116318
Protein sequencees
Ensembl_PRO: ENSMUSP00000112020, ENSMUSP00000119671
RefSeq: XP_017169681.1, XP_017169685.1, NP_001156790.1, XP_017169683.1, XP_017169682.1, XP_017169684.1
Others
UniRef100: UniRef100_Q00LT2
UniRef90: UniRef90_Q00LT2
UniRef50: UniRef50_Q00LT1
UniGene: Mm.390349
CCDS: CCDS48987.1

全选

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研究热度

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