| Type | Description |
|---|---|
| Definition | ryanodine receptor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:39:00 | Homer1 regulates RyR1 by direct interaction. | 31078268 |
| 2020-05-23 11:52:00 | Ryr1 RyR1-Q3970K formed caffeine-sensitive, Ca2+-conducting channel in HEK293 cells, but displayed low Ca2+-dependent channel activity and reduced activation by caffeine or ATP. RyR1-Q3970E, associated with arrhythmogenic syndrome in cardiac muscle, formed caffeine-induced Ca2+ release in HEK293 cells and exhibited low activity in the presence Ca2+ but, in contrast to RyR1-Q3970K, was activated by ATP and caffeine. | 31166712 |
| 2017-12-16 11:37:00 | In-depth structural analyses elucidated a novel channel-gating mechanism and a novel ion selectivity mechanism of RyR1. | 27573175 |
| 2017-12-16 10:55:00 | the cryo-electron microscopy structures of rabbit RyR1 in three closed conformations at about 4 A resolution and an open state at 5.7 A, are reported. | 27468892 |
| 2017-08-26 13:13:00 | Data suggest that RyR1 exhibits conformation consistent with an open-channel model sufficient for movement of Ca2+ except for a pore constriction site; molecular dynamics simulations suggest Ca2+ passage could be allowed by rotation of upper portion of pore-lining S6 helix away from 4-fold channel axis and twisting of Ile-4937 at channel constriction site out of the channel pore. | 28584051 |
| Type | IDs |
|---|---|
| Synonymous | RYR-1 |
| Gene |
UniProtKB-ID:
RYR1_RABIT
UniprotKB:
P11716
UniParc:
UPI000013C4CA
EMBL:
X15209,
X15750
KO:
ocu:100009540
|
| Nucleutide sequences |
EMBL-CDS:
CAA33279.1,
CAA33762.1
|
| Protein sequencees |
RefSeq:
NP_001095188.1
|
| Others |
UniRef100:
UniRef100_P11716
UniRef90:
UniRef90_P11716
UniRef50:
UniRef50_P11716
UniGene:
Ocu.2092
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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