| Type | Description |
|---|---|
| Definition | prion protein |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:54:00 | Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination. | 32513872 |
| 2018-11-03 10:58:00 | Bank vole asparagine and glutamine residues enable prion conversion of human and rabbit PrPC. | 28931606 |
| 2018-09-15 10:40:00 | Data indicates that protonation of the buried and highly conserved histidine destabilizes PRP leading to prion misfolding. | 28408762 |
| 2017-12-16 11:00:00 | study found 8 amino acid residues in rec-PrP that are probably involved in its low susceptibility to misfolding into a protease-resistant isoform; 3 of those residues (S107, M108, and I202) appear to have a stronger influence | 28978705 |
| 2012-11-24 11:00:00 | fibrils formed by the rabbit protein contain less beta-sheet structure and more alpha-helix structure than those formed by the proteins from human and cow; strong inhibition of fibrillization of the rabbit PrP by the crowded physiological environment and the absence of such a protease-resistant fragment for the rabbit protein could be why rabbits are resistant to prion diseases | 21943430 |
| Type | IDs |
|---|---|
| Synonymous | PRP |
| Gene |
UniProtKB-ID:
PRIO_RABIT,
Q9TSF8_RABIT
UniprotKB:
Q95211,
Q9TSF8
UniParc:
UPI0000033C28,
UPI000008854C
EMBL:
AF015603,
U28334
Ensembl:
ENSOCUG00000002086
KO:
ocu:100008658
|
| Nucleutide sequences |
EMBL-CDS:
AAC48697.1,
AAD01554.1
Ensembl_TRS:
ENSOCUT00000002082
|
| Protein sequencees |
Ensembl_PRO:
ENSOCUP00000001797
RefSeq:
NP_001075490.1,
XP_008254357.1,
XP_008254358.1
|
| Others |
UniRef100:
UniRef100_Q9TSF8,
UniRef100_Q95211
UniRef90:
UniRef90_Q95211,
UniRef90_P49927
UniRef50:
UniRef50_P04925
UniGene:
Ocu.6364
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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