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100005148 ar

100005148

ar

androgen receptor

protein-coding

Danio rerio

基因描述

Type Description
Definition androgen receptor

研究结论

Date Results Publications
2019-06-08 11:32:00 In summary, our results provided unequivocal in vivo evidence for the requirement of functional ar in maintaining normal spermatogenesis and steroidogenesis, in ensuring normal fertility in male zebrafish. 29228103
2019-03-30 10:58:00 Using glucose as a disease-relevant readout, we screened 2233 molecules and identified three that consistently reduced glucose levels in insulin mutants. Most significantly, we uncovered an insulin-independent beneficial role for androgen receptor antagonism in hyperglycemia, mostly by reducing fasting glucose levels. 30520733
2018-04-21 10:54:00 Zebrafish males lacking the androgen receptor courted females significantly less, showing reduced levels of stereotypic behaviors. Consistent with previous studies, disrupting androgen mechanisms can lead to behavioral changes with potential fitness consequences. 28620015
2018-02-17 11:19:00 AR regulates sexual determination, testis development, and oocyte maturation and AR regulates sexually dimorphic gene expression. The ar mutant developed will be useful for modeling human endocrine function in zebrafish. 29272351
2010-02-22 11:48:00 Findings suggest that zebrafish embryos attempt to compensate for the presence of an anti-androgen by increasing the number of androgen receptors available. 19818413

名称对应

Type IDs
Synonymous NR3C4
Gene
UniProtKB-ID: A4GT83_DANRE
UniprotKB: A4GT83
UniParc: UPI000024C9DB
EMBL: AL935051, EF427915, CR396593, CT025650
Ensembl: ENSDARG00000114287, ENSDARG00000067976
KO: dre:100005148
Nucleutide sequences
EMBL-CDS: ABO21097.1
Ensembl_TRS: ENSDART00000180137, ENSDART00000098022
Protein sequencees
Ensembl_PRO: ENSDARP00000146391, ENSDARP00000088795
RefSeq: XP_005171832.1, NP_001076592.1
Others
UniRef100: UniRef100_A4GT83
UniRef90: UniRef90_A4GT83
UniRef50: UniRef50_A4GT83
UniGene: Dr.75914

全选

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研究热度

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