A viral mechanism for inhibition of the cellular phosphatase calcineurin.
Science. 1998 Jul 24;281(5376):562-5. doi:10.1126/science.281.5376.562
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摘要
The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.
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基因功能
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原始数据
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文献解读
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