Cloning and characterization of Chinese hamster p53 cDNA.
Gene. 1997 Jan 15;184(2):177-83
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摘要
We have cloned and sequenced Chinese hamster p53 cDNA and have compared the p53 sequence in different Chinese hamster cell lines to several relevant phenotypes. Our results indicate that a mutation in CHO cells that changes Thr211 to Lys211 abrogates the ability to arrest in G1 and apparently renders cells capable of amplifying DNA. However, this mutation has no effect on the G2 checkpoint or on acute down-regulation of DNA replication after a radiation challenge.
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基因功能
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原始数据
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文献解读
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