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Nucleotide sequence of a cDNA clone (SUBT1) partly homologous to a human subtelomeric repeat sequence.

Biochem. Mol. Biol. Int.1996 May;39(2):303-6. doi:10.1080/15216549600201321
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摘要


Telomeres contains short tandem repeats (TTAGGG)n that are usually several kilobases in size. DNA sequences located next to the repeats are called telomere-associated or subtelomeric sequences. In this report we describe isolation and characterization of a new cDNA sequence isolated with a telomere specific, chromosome 17 genomic clone. No open reading frame of notable length could be detected. However comparison with sequences in the EMBL/Genbank revealed a 897 bp of close to perfect match, in the 3'end with the centromeric end of a genomic clone containing subtelomeric repeat sequences. The potential function of the SUBT1 transcript remains to be elucidated.

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