Characterization and inhibition of a cholecystokinin-inactivating serine peptidase.
Nature. 1996 Apr 4;380(6573):403-9. doi:10.1038/380403a0
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摘要
A cholecystokinin (CCK)-inactivating peptidase was purified and identified as a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10), a cytosolic subtilisin-like peptidase of previously unknown functions. The peptidase was found in neurons responding to cholecystokinin, as well as in non-neuronal cells. Butabindide, a potent and specific inhibitor, was designed and shown to protect endogenous cholecystokinin from inactivation and to display pro-satiating effects mediated by the CCKA receptor.
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基因功能
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原始数据
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文献解读
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