The ancient regulatory-protein family of WD-repeat proteins.

Nature. 1994 Sep 22;371(6495):297-300. doi:10.1038/371297a0

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摘要

WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.

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The ancient regulatory-protein family of WD-repeat proteins.

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