Requirement for intron-encoded U22 small nucleolar RNA in 18S ribosomal RNA maturation.
Science. 1994 Dec 02;266(5190):1558-61. doi:10.1126/science.7985025
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摘要
The nucleoli of vertebrate cells contain a number of small RNAs that are generated by the processing of intron fragments of protein-coding gene transcripts. The host gene (UHG) for intro-encoded human U22 is unusual in that it specifies a polyadenylated but apparently noncoding RNA. Depletion of U22 from Xenopus oocytes by oligonucleotide-directed ribonuclease H targeting prevented the processing of 18S ribosomal RNA (rRNA) at both ends. The appearance of 18S rRNA was restored by injection of in vitro-synthesized U22 RNA. These results identify a cellular function for an intron-encoded small RNA.
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基因功能
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原始数据
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文献解读
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