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Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase.

Genetics. 1995 Jun;140(2):527-35. doi:10.1093/genetics/140.2.527
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摘要

We characterized 18 genes from Caenorhabditis elegans that, when mutated, confer recessive resistance to inhibitors of acetylcholinesterase. These include previously described genes as well as newly identified genes; they encode essential as well as nonessential functions. In the absence of acetylcholinesterase inhibitors, the different mutants display a wide range of behavioral deficits, from mild uncoordination to almost complete paralysis. Measurements of acetylcholine levels in these mutants suggest that some of the genes are involved in presynaptic functions.

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