mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification.

Nature. 1983 Jul 28-Aug 3 ;304(5924):320-4. doi:10.1038/304320a0

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Light and heavy chain mRNAs of 15 anti-oxazolone antibodies were sequenced directly using synthetic primers. Hybridomas obtained 7 days after primary immunization show that they are of restricted heterogeneity. The majority expressed a single sequence with minor differences concentrated in the D region and joining boundaries D--JH and V kappa--J kappa.

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mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification.

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