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Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma.

Nature. 1980 Oct 16;287(5783):603-7. doi:10.1038/287603a0
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摘要

Leader, variable (V) and joining (J) gene segments, and adjacent regions of two rearranged alleles of the same kappa-chain producing mouse myeloma, comprising approximately 3,200 base pairs, have been sequenced. Sequence comparisons are reported. V-J joining in one of the alleles leads to a reading frame with a stop codon within the J-gene segments. Allelic exclusion is apparently realized in this tumour through the formation of such a non-functional allele.

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