Leumorphin is a novel endogenous opioid peptide derived from preproenkephalin B.

Biochem. Biophys. Res. Commun.1983 Dec 28;117(3):695-701

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Using synthetic leumorphin, we obtained antisera for leumorphin and set up two radioimmunoassays (RIAs) with different specificities. Gel exclusion chromatography coupled with the two RIAs showed the existence of a considerable amount of leumorphin-like peptide in water extracts from porcine neuro-intermediate pituitaries. Reverse phase high performance liquid chromatography revealed that leumorphin-like peptide in the water extracts was indistinguishable from synthetic leumorphin. These results along with potent opioid activity of leumorphin indicate that leumorphin is a novel endogenous opioid peptide derived from preproenkephalin B.

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Leumorphin is a novel endogenous opioid peptide derived from preproenkephalin B.

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