Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11.

Nucleic Acids Res.1985 Jan 25;13(2):381-7. doi:10.1093/nar/13.2.381

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We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the C lambda and some V lambda sequences translocate to the 8q+ chromosome whereas some V lambda sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that V lambda is proximal to C lambda.

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Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11.

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