Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.

Science. 1986 Aug 22;233(4766):859-66. doi:10.1126/science.3755548

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A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.

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Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.

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