Immunocytochemical Detection of ALK and ROS1 Rearrangements in Lung Cancer Cytological Samples.

Methods Mol Biol. 2021;2279:157-164. doi:10.1007/978-1-0716-1278-1_12

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The detection of molecular alterations such as and ALK rearrangements is performed as part of the diagnosis of advanced-stage lung adenocarcinoma. These alterations allow the treatments with tyrosine kinase inhibitors. Cytological samples are very useful as up to 40% patients are diagnosed with this type of sample. Here we describe the immunocytochemistry technique usable to reveal the overexpression of ALK or duanyu16701 tyrosine kinase receptors secondary to ALK and duanyu16701 rearrangements, respectively.

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Immunocytochemical Detection of ALK and ROS1 Rearrangements in Lung Cancer Cytological Samples.

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